CONSTRUCTION OF NOVEL PEPTOID ARCHITECTURES

新型类肽结构的构建

• 批准号: 7598700
• 负责人: Helen E. Blackwell
• 金额: $ 0.04万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598700
• 关键词: Adopted; Amides; Amines; Architecture; Computer Retrieval of Information on Scientific Projects Database; Facility Construction Funding Category; Funding; Grant; Homologous Gene; Institution; Molecular Conformation; Research; Research Personnel; Resources; Source; United States National Institutes of Health; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A straightforward synthesis has been developed for (S)-N-1-(pentafluorophenyl)ethyl amine that holds promise as a valuable chiral building block for the construction of novel peptoid architectures. This amine was incorporated successfully into a peptoid pentamer with alternating aromatic/perfluoroaromatic amide substituents. Structural characterization revealed that the peptoid pentamer can adopt a well-defined helical conformation analogous to that observed for considerably longer peptoid homologues.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 已经开发了（S）-N-1-（五氟苯基）乙胺的直接合成，其有望作为用于构建新型类肽结构的有价值的手性构建单元。这种胺被成功地纳入一个类肽五聚体与交替的芳族/全氟芳族酰胺取代基。结构表征表明，类肽五聚体可以采用类似于观察到的相当长的类肽同系物的明确定义的螺旋构象。