CONSTRUCTION OF NOVEL PEPTOID ARCHITECTURES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 (S)-N-1-(五氟苯基)乙胺的直接合成有望成为构建新型类肽结构的有价值的手性构建块。这种胺被成功地结合到具有交替的芳香族/全氟芳胺取代基的类肽五聚体中。结构表征表明，类肽五聚体可以采用定义明确的螺旋构象，类似于观察到的相当长的类肽同系物的构象。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A straightforward synthesis has been developed for (S)-N-1-(pentafluorophenyl)ethyl amine that holds promise as a valuable chiral building block for the construction of novel peptoid architectures. This amine was incorporated successfully into a peptoid pentamer with alternating aromatic/perfluoroaromatic amide substituents. Structural characterization revealed that the peptoid pentamer can adopt a well-defined helical conformation analogous to that observed for considerably longer peptoid homologues.