CONSTRUCTION OF NOVEL PEPTOID ARCHITECTURES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A straightforward synthesis has been developed for (S)-N-1-(pentafluorophenyl)ethyl amine that holds promise as a valuable chiral building block for the construction of novel peptoid architectures. This amine was incorporated successfully into a peptoid pentamer with alternating aromatic/perfluoroaromatic amide substituents. Structural characterization revealed that the peptoid pentamer can adopt a well-defined helical conformation analogous to that observed for considerably longer peptoid homologues.