MONTE CARLO ALGORITHM FOR VIRUS PARTICLE RECONSTRUCTION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The SAVR software package was developed for icosahedral virus particle reconstruction. This software has sucessfully solved several virus particle structures to sub-nanometer resolution. Continuous improvements are being made to make it more robust and universal. We are exploring the use of Monte Carlo algorithm to improve the efficiency and accuracy of the particle orientation search and refinement.