CANDIDATE GENE ANALYSIS OF ADVERSE OBSTETRICAL OUTCOMES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adverse pregnancy outcomes include pre-eclampsia, HELLP syndrome, abruptio placenta, placenta previa, intrauterine growth retardation, intrauterine fetal death, preterm labor, premature rupture of membranes and sepsis. To investigate genetic links to these conditions, two large-scale gene association studies are underway. Each involves the collection of clinical information and DNA on up to 2000 female patients with adverse outcome, their newborn, the newborn's father (in one study) and normal female controls. One cohort has been recruited in Chile; recruitment of the second cohort is planned for the U.S. In each sample, about 200 candidate genes will be tested for association to each subgroup defined by type of pregnancy complication. For each candidate gene, 1-3 SNPs will be genotyped. Planned analyses include case-control association analysis and transmission-disequilibrium testing to determine the role of the child's genotype and evaluate maternal/fetal genotypic interactions.