MRI OF MURINE CARDIAC FUNCTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 使用转基因小鼠研究心脏功能障碍的遗传基础，需要准确地表征心脏功能。在短时间的MRI成像过程中，很难实现每个心脏周期大于16个时间帧的高空间分辨率MRI。我们的假设是，快速采集、高时间分辨率的SPECT有足够的空间分辨率来准确地表征心功能的三维测量。这项初步研究的目的是将快速、高时间分辨率的SPECT测量的心功能(来自舒张末和收缩末期的LVEF和RVEF)与MRI获得的结果相关联。如果快速SPECT可以准确地表征心功能，将提出一种用于超声心动图初步筛查、SPECT用于二次功能表征和MRI用于高空间分辨率测量的算法，以全面表征转基因心力衰竭模型的心功能障碍。这一初步数据将用于赠款提案，以支持这些技术的进一步发展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Investigations of the genetic basis of cardiac dysfunction, using transgenic mice, require accurate characterization of ventricular function. High spatial resolution MRI of greater than 16 time frames per cardiac cycle is difficult to achieve in a short MRI imaging session. Our hypothesis is that rapid acquisition, high temporal resolution SPECT has sufficient spatial resolution to accurately characterize 3 dimensional measurements of cardiac function. The aim of this pilot study is to correlate rapid, high temporal resolution SPECT measurements of ventricular function (LVEF and RVEF from end-diastolic and end-systolic volumes) with those obtained by MRI. If rapid SPECT can accurately characterize cardiac function, an algorithm for echocardiography primary screening, SPECT for secondary functional characterization, and MRI for high spatial resolution measurements will be proposed to fully characterize cardiac dysfunction in transgenic models of heart failure. This preliminary data would be used in a grant proposal to support further development of these techniques.