MRI CORRELATES OF LIMB ISCHEMIA IN PVD

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本项目将利用动脉自旋标记（ASL）灌注MRI测量血管旁路手术前后外周血管疾病（PVD）患者腿部和足部骨骼肌的血流量。 为了可靠地测量肌肉灌注，本项目将使用全方位的成像技术，包括高场连续ASL。我们将检验以下假设：ASL可以通过脉冲动脉自旋标记或高场强下的调幅连续动脉自旋标记来实现，以利用增加的信号和分辨率，同时将射频沉积保持在标准范围内。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will utilize arterial spin labeled (ASL) perfusion MRI to measure blood flow in the skeletal muscle of the leg and foot in patients with peripheral vascular disease (PVD), before and after vascular bypass surgery. To reliably measure muscle perfusion, this project will make use of the full range of imaging techniqued including high field continuous ASL. We will test the hypothesis that ASL can be implemented via pulsed arterial spin labeling or amplitude modulated continuous arterial spin labeling at high field strength to take advantage of increased signal and resolution while maintaining radiofrequency deposition within standards.