MRI CORRELATES OF LIMB ISCHEMIA IN PVD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目将利用动脉自旋标记(ASL)灌注MRI来测量周围血管疾病(PVD)患者血管搭桥手术前后腿部和足部骨骼肌的血流量。为了可靠地测量肌肉灌注，该项目将利用包括高场连续ASL在内的全方位成像技术。我们将测试这一假设，即ASL可以在高场强下通过脉冲动脉自旋标记或调幅连续动脉自旋标记来实现，以利用更高的信号和分辨率，同时将射频沉积保持在标准范围内。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will utilize arterial spin labeled (ASL) perfusion MRI to measure blood flow in the skeletal muscle of the leg and foot in patients with peripheral vascular disease (PVD), before and after vascular bypass surgery. To reliably measure muscle perfusion, this project will make use of the full range of imaging techniqued including high field continuous ASL. We will test the hypothesis that ASL can be implemented via pulsed arterial spin labeling or amplitude modulated continuous arterial spin labeling at high field strength to take advantage of increased signal and resolution while maintaining radiofrequency deposition within standards.