BIOMOLECULAR INTERACTION AND GENE NETWORK SIMULATIONS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In the current proposal, we are requesting allocations for two different projects. 1. Insights into the mechanism of action of antimicrobial peptides from molecular dynamics simulations. This is a continuation of proposed work awarded with AAB resources in 2003, and NRAC resources in 2004 and 2005. We describe the results of the work so far, and the new systems we will investigate. 2. Design and simulations of artificial gene networks. This is a continuation of proposed work awarded with NRAC resources in 2004 and 2005.