BIOMOLECULAR INTERACTION AND GENE NETWORK SIMULATIONS

生物分子相互作用和基因网络模拟

• 批准号: 8364237
• 负责人: YIANNIS KAZNESSIS
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364237
• 关键词: Area; Award; Biomedical Research; Computer Simulation; Funding; Grant; High Performance Computing; National Center for Research Resources; Principal Investigator; Regulator Genes; Request for Proposals; Research; Research Infrastructure; Resources; Source; Synthetic Genes; United States National Institutes of Health; Work; antimicrobial peptide; cost; design; gene interaction; insight; model design; molecular dynamics; multi-scale modeling; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In the current proposal, we are requesting resources to continue working on two different projects. 1. Insights into the mechanism of action of antimicrobial peptides from molecular dynamics simulations. This is a continuation of proposed work awarded with AAB resources in 2003, and NRAC/TRAC resources in 2004, 2005, 2006, 2007, 2008 and 2009. The work completed to date has resulted in the PI being awarded an NIH R01 grant (R01GM070989, title: Computational Modeling and Design of Antimicrobial Peptides), which continues to support our work. We describe simulation efforts that we hope to pursue in the coming year. 2. Design and simulations of artificial gene networks. This is a continuation of proposed work awarded with NRAC/TRAC resources in 2004, 2005, 2006, 2007, 2008 and 2009. Work in this area was originally funded by a regular NSF grant (BES-0425882, title: Multiscale Modeling of Gene Regulatory Network) and is currently being supported by an NSF CAREER award (# 0644792) to YNK and a NIH R01 grant (1R01GM086865-01A2).

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 在当前的提案中，我们请求资源来继续开展两个不同的项目。 1.从分子动力学模拟洞察抗菌肽的作用机制。这是 2003 年 AAB 资源和 2004、2005、2006、2007、2008 和 2009 年 NRAC/TRAC 资源授予的拟议工作的延续。迄今为止完成的工作已使 PI 获得 NIH R01 拨款（R01GM070989，标题：抗菌药物的计算建模和设计）肽），继续支持我们的工作。我们描述了我们希望在来年进行的模拟工作。 2.人工基因网络的设计与模拟。这是 2004 年、2005 年、2006 年、2007 年、2008 年和 2009 年 NRAC/TRAC 资源授予的拟议工作的延续。该领域的工作最初由 NSF 常规拨款资助（BES-0425882，标题：基因调控网络的多尺度建模），目前得到 NSF 职业奖（# 0644792）的支持YNK 和 NIH R01 资助 (1R01GM086865-01A2)。