MOLECULAR GENETIC BASIS OF MYCOPLASMA ANTIGEN VARIATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 USDA ARS合作协议支持密苏里大学哥伦比亚分校的PPAID项目，该项目是由密苏里大学哥伦比亚分校、康涅狄格大学和梅子岛动物疾病中心组成的财团的一部分。相关次级项目的总体目标是获取和利用支原体系统发育簇的致病支原体和其他动物支原体的完整基因组序列，以了解和干预它们作为影响食用动物资源的严重疾病的病原体的作用。比较和后基因组技术以及标准分子方法被用于定义和评估与这些原核病原体的发病机制、改进的检测、疫苗开发和基础生物学有关的因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This USDA ARS cooperative agreement supports the PPAID program at the University of Missouri-Columbia as part of a consortium comprising the University of Missouri-Columbia, the University of Connecticut and the Plum Island Animal Disease Center. The overall objective of the pertinent subproject is to acquire and utilize the complete genomic sequence from pathogenic mycoplasmas of the M. mycoides phylogenetic cluster, and other animal mycoplasmas, in order to understand and intervene in their role as agents causing severe diseases affecting food animal resources. Comparative- and post-genomic technologies, along with standart molecular approaches, are applied to define and evaluate factors contributing to pathogenesis, improved detection, vaccine development and fundamental biology of these prokaryotic pathogens.