STRUCTURAL MAPPING OF CD134 BINDING RECEPTOR FOR BINDING OF FIV

用于结合 FIV 的 CD134 结合受体的结构作图

• 批准号: 7601709
• 负责人: John H Elder
• 金额: $ 0.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601709
• 关键词: Binding; CD4 Positive T Lymphocytes; CXCR4 gene; Computer Retrieval of Information on Scientific Projects Database; Family Felidae; Feline Immunodeficiency Virus; Funding; Grant; Human; Immunologic Deficiency Syndromes; Infection; Institution; Maps; Research; Research Personnel; Resources; Source; Specificity; United States National Institutes of Health; Virus; Virus Diseases; receptor binding

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. CD134 is a primary binding receptor for feline immunodeficiency virus (FIV), and with CXCR4 facilitates infection of CD4+ T cells. Human CD134 fails to support FIV infection. To delineate the regions important for defining virus specificity of CD134, we exchanged domains between human and feline CD134.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 CD 134是猫免疫缺陷病毒（FIV）的主要结合受体，并且与CXCR 4一起促进CD 4 + T细胞的感染。人CD 134不能支持FIV感染。为了描绘对定义CD 134的病毒特异性重要的区域，我们交换了人和猫CD 134之间的结构域。