STRUCTURAL MAPPING OF CD134 BINDING RECEPTOR FOR BINDING OF FIV

用于结合 FIV 的 CD134 结合受体的结构作图

• 批准号: 7955255
• 负责人: John H Elder
• 金额: $ 2.43万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955255
• 关键词: Binding; Biomedical Computing; CD4 Positive T Lymphocytes; CXCR4 gene; Computer Retrieval of Information on Scientific Projects Database; Family Felidae; Feline Immunodeficiency Virus; Funding; Grant; Human; Infection; Institution; Maps; Research; Research Personnel; Resources; Source; Specificity; United States National Institutes of Health; Virus; Virus Diseases; receptor binding

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. CD134 is a primary binding receptor for feline immunodeficiency virus (FIV), and with CXCR4 facilitates infection of CD4+ T cells. Human CD134 fails to support FIV infection. To delineate the regions important for defining virus specificity of CD134, we exchanged domains between human and feline CD134.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 CD134是猫免疫缺陷病毒(FIV)的主要结合受体，与CXCR4结合可促进CD4+T细胞的感染 细胞。人类CD134不支持FIV感染。描述对确定病毒特异性的重要区域 CD134，我们在人和猫之间交换了CD134结构域。