SPB LOCALIZATION OF HSL7

HSL7 的 SPB 本地化

• 批准号: 7602106
• 负责人: AMY E TROTT
• 金额: $ 0.87万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7602106
• 关键词: Binding; Cell Cycle; Computer Retrieval of Information on Scientific Projects Database; Event; Funding; Goals; Grant; Institution; Localized; Mitosis; Mitotic; Neck; Proteins; Research; Research Personnel; Resources; Role; Signal Transduction; Source; Subcellular structure; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hsl7 during much of the cell cycle is tethered to the bud neck via Hsl1. Interestingly, V. Cid et al., observed that during G1, prior to Hsl7's arrival at the bud neck, Hsl7 localizes to the SPB. While most of the identified components of the SPB have obvious structural roles, several examples of proteins with regulatory/signaling roles that localize to this subcellular structure have also been characterized. A subset of these include proteins that localize to the SPB specifically during M phase and are involved in coordinating SPB dynamics with late mitotic events. The finding that Hsl7 localizes to the SPB during G1 suggests a yet uncharacterized role for Hsl7. The goal is characterizing the binding of Hsl7 to the SPB.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在细胞周期的大部分时间内，Hsl 7通过Hsl 1与芽颈相连。 有趣的是，V. Cid等人，观察到，在 G1，在Hsl 7到达芽颈之前，Hsl 7定位于SPB。 虽然SPB的大多数已确定的组件 具有明显的结构作用，几个具有调节/信号作用的蛋白质的例子定位于这个亚细胞， 结构也已被表征。 这些蛋白质的一个子集包括在M期特异性定位于SPB的蛋白质 阶段，并参与协调SPB动力学与晚期有丝分裂事件。 Hsl 7定位于SPB的发现 在G1期间表明Hs 17的尚未表征的作用。目标是表征Hsl 7与SPB的结合。