EXAMINING THE NEURAL BASES OF AMUSEMENT AND SADNESS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 全文标题：检验娱乐和悲伤的神经基础：块对比和动态情绪强度的放射回归方法比较 神经成像研究在阐明情绪的神经基础方面取得了实质性进展。然而，到目前为止，还没有一项研究考虑到情绪体验的特殊性和时变性。在这项研究中，我们使用功能磁共振成像来研究两种常见情绪的神经基础：娱乐和悲伤，使用(A)传统的基于刺激的块对比方法，以及(B)一种新的特定于受试者的、连续的、动态的情绪强度评级具体回归方法。13名女性两次观看了9个2分钟的搞笑、悲伤或中性的电影片段。在第一次观看时，参与者只看了电影。在第二次观看时，他们对第一次观看电影期间经历的娱乐和悲伤强度进行了连续的动态评级。整体分析和具体回归分析表明，悲伤电影与内侧前额叶(PFC)、楔前叶、枕腹叶、杏仁核和丘脑的激活有关，而有趣的电影主要与左侧PFC和颞叶的激活有关。虽然在悲伤电影中，具体的回归方法检测到了与阻滞法相似的区域，但它揭示了比起娱乐电影的阻滞法，大脑皮质下和大脑内侧的PFC区域更多的激活。这些结果表明，情绪特定的时间动力学与不同数据分析方法的敏感性之间存在关系，这些方法用于识别不同的皮质和皮质下激活区域。这些发现揭示了情绪的神经基础，并提出了一种新的方法来研究情绪反应的动态方面，这些情绪反应在不同的个体之间存在着巨大的差异。 这项研究得到了NIMH基金MH58147的支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. FULL TITLE: Examining the Neural Bases of Amusement and Sadness: A Comparison of Block Contrast and Dynamic Emotion Intensity Idiographic Regressor Approaches Neuroimaging studies have made substantial progress in elucidating the neural bases of emotion. However, no study to date has taken into account the idiosyncratic, time-varying nature of emotional experience. In the present study, we employed functional magnetic resonance imaging to examine the neural bases of two common emotions: amusement and sadness using both (a) a conventional stimulus-based block contrast approach, and (b) a novel subject-specific, continuous, dynamic emotion intensity rating idiographic regressor approach. Thirteen women twice viewed a set of nine 2-minute amusing, sad, or neutral film clips. On first viewing, participants just watched the films. On second viewing, they made continuous dynamic ratings of amusement and sadness intensity experienced during the first film viewing. Whole-block and idiographic regressor approaches revealed in common that sad films were associated with activations in medial prefrontal cortex (PFC), precuneus, ventral occipital cortex, amygdala and thalamus, and that amusing films were associated predominantly with activations in left PFC and temporal lobes. While the idiographic regressor detected regions similarly identified by the block approach during sad films, it revealed more subcortical and medial PFC areas of activation than the block approach for amusing films. These results suggest a relationship between emotion-specific temporal dynamics and the sensitivity of different data analytic methods for identifying distinct cortical and subcortical regions of activation. These findings shed light on the neural bases of emotion, and suggest a new approach for examining the dynamic aspects of emotional responses that differ so dramatically across individuals. This research was supported by NIMH grant MH58147.