EXAMINING THE NEURAL BASES OF AMUSEMENT AND SADNESS

检查娱乐和悲伤的神经基础

• 批准号: 7601873
• 负责人: PHILIPPE R GOLDIN
• 金额: $ 0.58万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601873
• 关键词: Accounting; Amygdaloid structure; Area; Clip; Computer Retrieval of Information on Scientific Projects Database; Data; Depressed mood; Emotional; Emotions; Film; Functional Magnetic Resonance Imaging; Funding; Grant; Individual; Institution; Left; Light; Lobe; Medial; Methods; National Institute of Mental Health; Nature; Occipital lobe; Participant; Prefrontal Cortex; Rate; Research; Research Personnel; Resources; Source; Stimulus; Thalamic structure; Time; Title; United States National Institutes of Health; Woman; base; emotional experience; experience; neuroimaging; novel; novel strategies; relating to nervous system; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. FULL TITLE: Examining the Neural Bases of Amusement and Sadness: A Comparison of Block Contrast and Dynamic Emotion Intensity Idiographic Regressor Approaches Neuroimaging studies have made substantial progress in elucidating the neural bases of emotion. However, no study to date has taken into account the idiosyncratic, time-varying nature of emotional experience. In the present study, we employed functional magnetic resonance imaging to examine the neural bases of two common emotions: amusement and sadness using both (a) a conventional stimulus-based block contrast approach, and (b) a novel subject-specific, continuous, dynamic emotion intensity rating idiographic regressor approach. Thirteen women twice viewed a set of nine 2-minute amusing, sad, or neutral film clips. On first viewing, participants just watched the films. On second viewing, they made continuous dynamic ratings of amusement and sadness intensity experienced during the first film viewing. Whole-block and idiographic regressor approaches revealed in common that sad films were associated with activations in medial prefrontal cortex (PFC), precuneus, ventral occipital cortex, amygdala and thalamus, and that amusing films were associated predominantly with activations in left PFC and temporal lobes. While the idiographic regressor detected regions similarly identified by the block approach during sad films, it revealed more subcortical and medial PFC areas of activation than the block approach for amusing films. These results suggest a relationship between emotion-specific temporal dynamics and the sensitivity of different data analytic methods for identifying distinct cortical and subcortical regions of activation. These findings shed light on the neural bases of emotion, and suggest a new approach for examining the dynamic aspects of emotional responses that differ so dramatically across individuals. This research was supported by NIMH grant MH58147.

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