EXAMINING THE NEURAL BASES OF AMUSEMENT AND SADNESS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 完整标题：检查娱乐和悲伤的神经基础：块对比和动态情绪强度特征回归方法的比较 神经影像学研究在阐明情绪的神经基础方面取得了实质性进展。然而，迄今为止还没有研究考虑到情绪体验的特殊性和随时间变化的性质。在本研究中，我们采用功能磁共振成像检查两种常见情绪的神经基础：娱乐和悲伤，使用（a）传统的基于刺激的块对比方法，和（B）一种新的主题特定的，连续的，动态的情绪强度评级具体的回归方法。13名女性两次观看了一组9个2分钟的有趣，悲伤或中性的电影片段。在第一次观看时，参与者只是观看电影。在第二次观看时，他们对第一次观看电影期间经历的娱乐和悲伤强度进行了连续的动态评级。整体块和具体的回归方法显示，在共同的悲伤电影与激活内侧前额叶皮层（PFC），楔前叶，腹枕叶皮层，杏仁核和丘脑，有趣的电影主要与激活左侧PFC和颞叶。虽然具体的回归检测区域同样确定的块的方法在悲伤的电影，它揭示了更多的皮质下和内侧PFC区的激活比块的方法为有趣的电影。这些结果表明，特定于情绪的时间动态与用于识别不同皮质和皮质下激活区域的不同数据分析方法的灵敏度之间存在关系。这些发现揭示了情绪的神经基础，并提出了一种新的方法来检查情绪反应的动态方面，这些情绪反应在个体之间差异如此之大。 这项研究得到了NIMH基金MH 58147的支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. FULL TITLE: Examining the Neural Bases of Amusement and Sadness: A Comparison of Block Contrast and Dynamic Emotion Intensity Idiographic Regressor Approaches Neuroimaging studies have made substantial progress in elucidating the neural bases of emotion. However, no study to date has taken into account the idiosyncratic, time-varying nature of emotional experience. In the present study, we employed functional magnetic resonance imaging to examine the neural bases of two common emotions: amusement and sadness using both (a) a conventional stimulus-based block contrast approach, and (b) a novel subject-specific, continuous, dynamic emotion intensity rating idiographic regressor approach. Thirteen women twice viewed a set of nine 2-minute amusing, sad, or neutral film clips. On first viewing, participants just watched the films. On second viewing, they made continuous dynamic ratings of amusement and sadness intensity experienced during the first film viewing. Whole-block and idiographic regressor approaches revealed in common that sad films were associated with activations in medial prefrontal cortex (PFC), precuneus, ventral occipital cortex, amygdala and thalamus, and that amusing films were associated predominantly with activations in left PFC and temporal lobes. While the idiographic regressor detected regions similarly identified by the block approach during sad films, it revealed more subcortical and medial PFC areas of activation than the block approach for amusing films. These results suggest a relationship between emotion-specific temporal dynamics and the sensitivity of different data analytic methods for identifying distinct cortical and subcortical regions of activation. These findings shed light on the neural bases of emotion, and suggest a new approach for examining the dynamic aspects of emotional responses that differ so dramatically across individuals. This research was supported by NIMH grant MH58147.