STRUCTURAL STUDIES ON DYNEIN-MICROTUBULE COMPLEX

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 基于微管的马达，动力蛋白，是纳米级的蛋白质机器，并将来自ATP水解的化学能转化为机械运动。机械运动用于各种基本的细胞内运动，如轴突运输，染色体分离和鞭毛运动。由于动力蛋白或动力蛋白相关蛋白的突变引起的几种动力蛋白相关疾病强调了动力蛋白功能的重要性。然而，人们对突变如何导致疾病知之甚少。甚至动力蛋白如何将化学能转化为机械运动的基本问题也没有得到很好的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Microtubule-based motors, dyneins, are nano-meter scale protein machineries and convert chemical energy derived from ATP hydrolysis to mechanical movement. The mechanical movement is employed for various essential intracellular motilities, such as axonal transport, chromosome segregation, and flagellar motility. The importance of dynein functions is underlined by several dynein-related diseases caused by mutation in dynein or dynein-associated proteins. However, little is known about how the mutations cause diseases. Even a basic question of how dyneins convert chemical energy to mechanical movement is not well understood.