STRUCTURAL AND FUNCTIONAL STUDIES OF EUKARYOTIC PHOSPHOFRUCTOKINASE
STRUCTURAL AND FUNCTIONAL STUDIES OF EUKARYOTIC PHOSPHOFRUCTOKINASE
批准号:
7602769
负责人:
TERESA RUIZ
金额:
$1.79万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-08-13 至 2008-07-31
关键词:
Computer Retrieval of Information on Scientific Projects DatabaseEnergy-Generating ResourcesEnzymesFructoseFundingGlycolysisGrantInstitutionLeadPhosphorylationPlayRegulationResearchResearch PersonnelResourcesRoleSourceStructure-Activity RelationshipUnited States National Institutes of Healthcancer cellcancer typefructose-6-phosphatenovel
中文摘要
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
磷酸果糖激酶(Pfk1)催化糖酵解的关键调节步骤,即在三磷酸腺苷存在下将果糖6-磷酸(F6P)磷酸化为果糖1,6-二磷酸。Pfk1的酶活性受多种变构效应调控,表明该酶在糖酵解通量的调节中起着关键作用。糖酵解是癌细胞的主要能量来源。因此,彻底了解Pfk1的结构/功能关系可能会导致对某些类型的癌症进行新的、更有效的治疗。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Phosphofructokinase (Pfk1) catalyzes a crucial regulatory step of glycolysis, the phosphorylation of fructose 6-phosphate (F6P) to fructose 1,6-biphosphate in the presence of ATP. The enzymatic activity of Pfk1 is controlled by many allosteric effectors, evidencing the key role that the enzyme plays in the regulation of the glycolytic flux. Glycolysis is the main energy source of cancer cells. Thus, a thorough understanding of the structure/function relationship in Pfk1 may lead to novel and more effective treatments for certain types of cancer.
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EUKARYOTIC PHOSPHOFRUCTOKINASE: STRUCTURE/FUNCTION
-
批准号:7924304
-
项目类别:
-
资助金额:$19.64万
-
财政年份:2009
-
负责人:TERESA RUIZ
-
依托单位:
STRUCTURE OF ORAL BACTERIAL ADHESINS
-
批准号:8075601
-
项目类别:
-
资助金额:$34.32万
-
财政年份:2008
-
负责人:TERESA RUIZ
-
依托单位:
STRUCTURE OF ORAL BACTERIAL ADHESINS
-
批准号:7522528
-
项目类别:
-
资助金额:$35.02万
-
财政年份:2008
-
负责人:TERESA RUIZ
-
依托单位:
STRUCTURE OF ORAL BACTERIAL ADHESINS
-
批准号:8270371
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项目类别:
-
资助金额:$35.03万
-
财政年份:2008
-
负责人:TERESA RUIZ
-
依托单位:
STRUCTURE OF ORAL BACTERIAL ADHESINS
-
批准号:7845028
-
项目类别:
-
资助金额:$35.39万
-
财政年份:2008
-
负责人:TERESA RUIZ
-
依托单位:
STRUCTURE OF ORAL BACTERIAL ADHESINS
-
批准号:7658922
-
项目类别:
-
资助金额:$35.26万
-
财政年份:2008
-
负责人:TERESA RUIZ
-
依托单位:
EUKARYOTIC PHOSPHOFRUCTOKINASE: STRUCTURE/FUNCTION
-
批准号:6931097
-
项目类别:
-
资助金额:$24.32万
-
财政年份:2004
-
负责人:TERESA RUIZ
-
依托单位:
EUKARYOTIC PHOSPHOFRUCTOKINASE: STRUCTURE/FUNCTION
-
批准号:6820267
-
项目类别:
-
资助金额:$23.49万
-
财政年份:2004
-
负责人:TERESA RUIZ
-
依托单位:
EUKARYOTIC PHOSPHOFRUCTOKINASE: STRUCTURE/FUNCTION
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批准号:7104812
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项目类别:
-
资助金额:$23.75万
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财政年份:2004
-
负责人:TERESA RUIZ
-
依托单位:
EUKARYOTIC PHOSPHOFRUCTOKINASE: STRUCTURE/FUNCTION
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批准号:7478035
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项目类别:
-
资助金额:$23.06万
-
财政年份:2004
-
负责人:TERESA RUIZ
-
依托单位:
EUKARYOTIC PHOSPHOFRUCTOKINASE: STRUCTURE/FUNCTION
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批准号:7269535
-
项目类别:
-
资助金额:$23.06万
-
财政年份:2004
-
负责人:TERESA RUIZ
-
依托单位:
STRUCTURE & DYNAMICS OF CENTRIOLE
-
批准号:6653370
-
项目类别:
-
资助金额:$29.46万
-
财政年份:2002
-
负责人:TERESA RUIZ
-
依托单位:
STRUCTURE & DYNAMICS OF CENTRIOLE
-
批准号:6491853
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项目类别:
-
资助金额:$29.46万
-
财政年份:2001
-
负责人:TERESA RUIZ
-
依托单位:
STRUCTURE & DYNAMICS OF CENTRIOLE
-
批准号:6423436
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项目类别:
-
资助金额:$29.46万
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财政年份:2000
-
负责人:TERESA RUIZ
-
依托单位:
STRUCTURE & DYNAMICS OF CENTRIOLE
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批准号:6119674
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项目类别:
-
资助金额:$0.85万
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财政年份:1999
-
负责人:TERESA RUIZ
-
依托单位:
STRUCTURE & DYNAMICS OF CENTROSOME
-
批准号:6280705
-
项目类别:
-
资助金额:$1.08万
-
财政年份:1998
-
负责人:TERESA RUIZ
-
依托单位: