SINGLE PARTICLE RECONSTRUCTION OF CONNEXIN 26

CONNEXIN 26 的单粒子重建

• 批准号: 7602742
• 负责人: MARK D YEAGER
• 金额: $ 0.89万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-13 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7602742
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Connexins; Cryoelectron Microscopy; Family member; Funding; Goals; Grant; Institution; Ion Channel; Mutation; Proteins; Research; Research Personnel; Resolution; Resources; Source; Structure; United States National Institutes of Health; deafness; human GJB2 protein; particle; reconstruction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Connexin is one of the members of the family of gap junction proteins. It is a transmembrane channel and mutations in this protein causes deafness Our goal is to obtain a high resolution structure of this membrane channel using cryo electron microscopy.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 连接蛋白是缝隙连接蛋白家族的成员之一。 它是一种跨膜通道，这种蛋白质的突变会导致耳聋。我们的目标是利用冷冻电子显微镜获得这种膜通道的高分辨率结构。