Pulse wave velocity in chronic kidney disease

慢性肾脏病的脉搏波速度

• 批准号: 7626451
• 负责人: Raymond R Townsend
• 金额: $ 44.56万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2010-09-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7626451
• 关键词: Adult; Amputation; Aorta; Appearance; Blood Circulation; Blood Pressure; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Chronic Kidney Failure; Chronic Kidney Insufficiency; Cohort Studies; Creatinine; Data; Devices; Dialysis patients; Dialysis procedure; Diastolic blood pressure; Dietary Proteins; Disease; Disease Outcome; Disease Progression; Drug usage; Elderly; Enrollment; Epidemiology; Etiology; Event; Future; Glomerular Filtration Rate; Goals; Heart Diseases; Heart failure; Impairment; Intake; Intervention; Iothalamate; Kidney; Kidney Diseases; Kidney Failure; Kidney Transplantation; Lower Extremity; Measurement; Measures; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; Outcome; Patients; Physiologic pulse; Population; Preventive; Procedures; Proteinuria; Pulse Pressure; Renal function; Research Personnel; Risk Factors; Role; Serum; Severities; Site; Stroke; Subgroup; Testing; Time; Travel; base; cohort; effective intervention; experience; high risk; hypertension treatment; improved; predictive modeling; programs; treatment trial

DESCRIPTION (provided by applicant): The National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) established the Chronic Renal Insufficiency Cohort Study in 2001. The principal goals of the CRIC Study are to examine risk factors for chronic kidney disease (CKD) progression (i.e. further loss of kidney function) and cardiovascular events among patients with varying severity of CKD, and develop predictive models that will identify high-risk subgroups with CKD. The latter results will target enrollment of high-risk subjects into future treatment trials and increase application of available preventive therapies. Hypertension treatment has been the most effective intervention altering the course of renal function loss in CKD. However, the drugs used in the treatment of hypertension differ in their benefits on renal function. This raises the possibility that blood pressure reduction by itself only partly explains their beneficial effect and beckons a broader understanding of vascular adaptation to diseases such as CKD. Determination of the pulse wave velocity (PWV) a reflection of large vessel stiffness has provided useful information in cardiovascular disease epidemiology.

描述（由申请人提供）： 国家糖尿病、消化和肾脏疾病研究所（NIDDK）于2001年建立了慢性肾功能不全队列研究。CRIC研究的主要目标是检查慢性肾脏病（CKD）进展（即肾功能进一步丧失）和不同严重程度CKD患者心血管事件的风险因素，并开发预测模型，以识别CKD高风险亚组。后者的结果将针对未来治疗试验招募高风险受试者，并增加可用预防疗法的应用。高血压治疗是改变CKD患者肾功能丧失过程的最有效干预措施。然而，用于治疗高血压的药物对肾功能的益处不同。这提出了一种可能性，即血压降低本身只能部分解释其有益效果，并呼吁更广泛地理解血管对CKD等疾病的适应性。脉搏波传导速度（PWV）反映了大血管的硬度，它的测定为心血管疾病的流行病学研究提供了有用的信息。