Improving Medication Adherence for Patients with Low Functional Health Literacy:

提高功能健康素养低下患者的药物依从性：

• 批准号: 7694382
• 负责人: Seth Wolpin
• 金额: $ 15.6万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-29 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7694382
• 关键词: Adherence; Blood Pressure; Clinical Trials; Clinical Trials Design; Data; Development; Equipment; Essential Hypertension; Future; Healthcare; Home environment; Instruction; Intervention; Interview; Label; Life; Measures; Outcome; Pacific Northwest; Patients; Pharmaceutical Preparations; Pharmacy facility; Pilot Projects; Play; Procedures; Proxy; Randomized; Randomized Controlled Clinical Trials; Randomized Controlled Trials; Reading; Research; Research Project Grants; Role; Self Efficacy; Self Management; Site; Solutions; Structure; Technology; Testing; Treatment Protocols; Upper arm; blood pressure regulation; design; functional health literacy; health literacy; improved; literacy; medication compliance; novel; pill; pilot trial; public health relevance; skills; treatment as usual

DESCRIPTION (provided by applicant): A Pilot Study with Talking Pill Bottles Introduction: Across the healthcare continuum, patients with low functional health literacy may have worse outcomes due to difficulties in following prescribed medication regimens. While reasons for non-adherence can be drawn from the intra-personal, interpersonal, and systemic perspectives; one starting point is the difficulty that patients have reading and understanding medication instructions on a prescription bottle labels. Labels can provide a vital reminder and decision support aid for patients and healthcare proxies. Yet, skills must be available for reading and understanding the labels. We will utilize "Talking Pill Bottles" to record prescription medication instructions so that patients can re-play the instructions as needed in their homes. Purpose: The aim of this research project is to compare the use of "Talking Pill Bottles" to usual care in patients who have low functional health literacy and who purchase medications for primary hypertension at a retail pharmacy with regard to: a. feasibility of the procedures, b. utility of the equipment, c. medication adherence, d. self efficacy in medication self management, and e. blood pressure control. Design: This novel intervention will be tested within the context of a retail pharmacy in the Pacific Northwest. The pilot test will use a randomized trial design with two research arms. Analysis: Within-group change scores on a self efficacy measure and blood pressures will be examined with the paired t-test; between group measures will also be examined between the two treatment arms. We will also track medication complexity as a potential confounder and conduct semi- structured exit interviews. Conclusion: Results will help establish the feasibility and utility of providing this technology to patients who have low functional health literacy in a retail pharmacy. We will gather preliminary descriptive data along with variance and effect size measures for power estimations in a future multi-site, randomized controlled trial. PUBLIC HEALTH RELEVANCE: Patients with low functional health literacy often have worse outcomes due to difficulties in adhering to prescribed medication regimens. We will utilize "Talking Pill Bottles" (i.e., medication containers with re-recordable audio capacity) to record prescription medication instructions so that patients can re-play the instructions as needed in their homes.

描述（由申请人提供）：一项使用会说话的药瓶的试点研究介绍：在整个医疗保健连续体中，功能性健康素养低的患者可能会因为难以遵循处方药物治疗方案而导致更差的结果。虽然不依从的原因可以从个人、人际和系统的角度得出;一个出发点是患者难以阅读和理解处方瓶标签上的药物说明。标签可以为患者和医疗保健代理人提供重要的提醒和决策支持帮助。然而，必须具备阅读和理解标签的技能。我们将利用“会说话的药瓶”来记录处方药说明，以便患者可以在家中根据需要重新播放说明。用途：该研究项目的目的是比较“会说话的药瓶”的使用与具有低功能健康素养并且在零售药店购买原发性高血压药物的患者的常规护理，关于：a.程序的可行性，B.设备的使用，C。药物依从性，d.药物自我管理的自我效能;血压控制。设计：这种新的干预措施将在太平洋西北部的零售药店的背景下进行测试。初步试验将采用随机试验设计，包括两个研究组。分析：将采用配对t检验检查自我效能指标和血压的组内变化评分;还将检查两个治疗组之间的组间指标。我们还将跟踪药物复杂性作为潜在的混杂因素，并进行半结构化的离职面谈。结论：结果将有助于建立提供这种技术的可行性和实用性，谁在零售药店功能健康素养低的患者。我们将收集初步的描述性数据，沿着方差和效应量指标，以便在未来的多中心随机对照试验中进行把握度估计。公共卫生关系：功能性健康素养低的患者往往由于难以坚持处方药物治疗方案而导致结局更差。我们将利用“会说话的药瓶”（即，具有可重录音频容量的药物容器）来记录处方药物说明，使得患者可以根据需要在其家中重放说明。