Efficacy of Laryngeal High-Speed Videoendoscopy

喉高速视频内窥镜的疗效

• 批准号: 7558934
• 负责人: DIMITAR D DELIYSKI
• 金额: $ 48.15万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7558934
• 关键词: Acoustics; Address; Adopted; Adoption; Affect; Agreement; Area; Behavior; Behavioral; Biomechanics; Bite; Calibration; Characteristics; Classification Scheme; Clinic; Clinical; Clinical Protocols; Clinical Research; Clinical assessments; Collaborations; Color; Complement; Computer Simulation; Computers; Data; Databases; Detection; Devices; Diagnosis; Diagnostic; Endoscopes; Evaluation; Excision; Financial compensation; Functional disorder; General Hospitals; Gold; Healthcare; Image; Image Analysis; Imagery; Investigation; Kymography; Larynx; Lead; Left; Length; Light; Massachusetts; Measurement; Measures; Medial; Medical; Methods; Modeling; Motion; Participant; Pathology; Patients; Performance; Persons; Phonation; Physiological; Presbyterian Church; Procedures; Production; Protocols documentation; Recording of previous events; Relative (related person); Research; Resolution; Rotation; Sampling; Scientist; Series; South Carolina; Speed; Stroboscopy; Structure; System; Techniques; Technology; Testing; Training; Universities; Validation; Validity and Reliability; Visual; Voice; Voice Disorders; Width; base; clinical practice; clinical research site; clinically relevant; digital; human data; improved; indexing; insight; next generation; research study; simulation; sound; tool; tool development; vibration; vocal cord

DESCRIPTION (provided by applicant): Voice disorders result from the disruption of normal vocal fold vibration during phonation. The current gold standard for assessing voice disorders is visual endoscopic examination via videostroboscopy. However, technical limitations that are inherent to stroboscopic imaging (i.e., generating a composite image that is assembled across many cycles of vibration) restrict the clinical and research utility of videostroboscopy. High-speed imaging has the potential to capture the true cycle-to-cycle vibratory behavior of the vocal folds, which should theoretically overcome the limitations of videostroboscopy, and provide the potential for more accurate objective quantification of vocal fold vibratory behavior. Vocal fold high-speed imaging has a long research history, and the relatively recent commercial introduction of laryngeal high-speed videoendoscopy (HSV) has served to increase its availability for clinical and research use. However, these HSV systems have not gained widespread adoption because of remaining methodological limitations (eg., compromised image quality; lack of tools to extract the rich visual content, difficulty managing and analyzing the massive amounts of data generated by HSV, etc.), and an associated lack of information regarding the validity, practicality, and clinical relevance of HSV. The primary purpose of this project is to develop improved HSV-based methods for the visualization and automatic measurement of vocal fold vibratory characteristics that will facilitate the clinical and research use of this technology, and to begin establishing the clinical validity, practicality, and relevance of HSV in the functional evaluation of vocal fold pathology. The overriding hypothesis is that HSV can be developed into a robust tool that will provide new insights into the biomechanics of laryngeal sound production (particularly when combined with other simultaneous measures), as well as enable more accurate functional assessment of the pathophysiology of voice disorders leading to important refinements in the diagnosis of vocal fold pathology. The primary purpose requires a series of experiments to improve HSV technology, develop analysis techniques, establish a clinical protocol, collect data, and evaluate the reliability, validity, and relevance of HSV in the clinical assessment of voice disorders. This project proposes a comprehensive approach addressing all of the above tasks, through the collaboration of leading scientists and clinicians.

描述（由申请人提供）： 声音障碍是由于发声过程中正常声带振动的破坏引起的。目前评估声音障碍的黄金标准是通过视频频闪镜进行视觉内窥镜检查。然而，频闪成像固有的技术限制（即生成跨多个振动周期组装的合成图像）限制了视频频闪成像的临床和研究实用性。高速成像有潜力捕捉声带真实的周期振动行为，理论上应该克服视频频闪镜的局限性，并为声带振动行为的更准确客观量化提供潜力。声带高速成像有着悠久的研究历史，最近喉部高速视频内窥镜 (HSV) 的商业引入提高了其临床和研究用途的可用性。然而，由于方法学上的局限性（例如，图像质量受损；缺乏提取丰富视觉内容的工具，难以管理和分析 HSV 生成的大量数据等），以及缺乏有关 HSV 有效性、实用性和临床相关性的相关信息，这些 HSV 系统尚未获得广泛采用。该项目的主要目的是开发改进的基于 HSV 的方法，用于声带振动特征的可视化和自动测量，这将促进该技术的临床和研究使用，并开始建立 HSV 在声带病理功能评估中的临床有效性、实用性和相关性。最重要的假设是，HSV 可以发展成为一种强大的工具，为喉部发声的生物力学提供新的见解（特别是与其他同步测量相结合时），并能够对声音疾病的病理生理学进行更准确的功能评估，从而对声带病理学的诊断产生重要的改进。主要目的需要进行一系列实验来改进HSV技术、开发分析技术、建立临床方案、收集数据并评估HSV在声音障碍临床评估中的可靠性、有效性和相关性。该项目提出了一种通过领先科学家和临床医生的合作来解决所有上述任务的综合方法。