EFFECT OF CHRONIC MACROLIDE ADMINISTRATION ON COPD EXACERBATIONS

长期服用大环内酯对 COPD 急性加重的影响

• 批准号: 7604350
• 负责人: RICHARD K ALBERT
• 金额: $ 4.14万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604350
• 关键词: Acute; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-inflammatory; Azithromycin; Chronic; Chronic Obstructive Airway Disease; Computer Retrieval of Information on Scientific Projects Database; Controlled Clinical Trials; Double-Blind Method; Funding; Grant; Institution; Macrolide Antibiotics; Macrolides; Morbidity - disease rate; Placebo Control; Placebos; Prevalence; Property; Randomized; Research; Research Personnel; Resources; Source; Treatment Cost; United States National Institutes of Health; clinical research site; cost; day; mortality; prospective; theories

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to determine if chronic administration of a macrolide antibiotic will reduce the morbidity of COPD. This will be a prospective, randomized, double-blind, placebo-controlled clinical trial. A total of 1130 subjects at 7 clinical sites with at least moderately severe COPD will be randomized to either azithromycin 250mg every day or matching placebo. The rationale for this study is that the prevalence, morbidity, mortality, and treatment costs of COPD are high and increasing. A large portion of the morbidity and costs are related to acute exacerbations. Macrolide antibiotics have a variety of antibacterial and anti-inflammatory properties that in theory could reduce acute exacerbations.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是确定长期使用大环内酯类抗生素是否会降低COPD的发病率。 这将是一项前瞻性、随机、双盲、安慰剂对照临床试验。 7个临床试验机构的1130例至少为中重度COPD的受试者将随机接受阿奇霉素250 mg/天或匹配安慰剂治疗。 这项研究的基本原理是COPD的患病率、发病率、死亡率和治疗费用都很高，而且还在增加。 很大一部分发病率和费用与急性加重有关。 大环内酯类抗生素具有多种抗菌和抗炎特性，理论上可以减少急性加重。