Khat Chewing: Its Association with HIV Status and CD4 T Cells

咀嚼卡塔叶：它与 HIV 状态和 CD4 T 细胞的关联

• 批准号: 7693805
• 负责人: Della Berhanu
• 金额: $ 1.02万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7693805
• 关键词: AIDS/HIV problem; Address; Adult; Age; Alcohol consumption; Behavior; Behavioral; Blood specimen; CD4 Positive T Lymphocytes; Catha edulis; Cell Count; Chemoprophylaxis; Cigarette; Client; Consent; Counseling; Cross-Sectional Studies; Development; Disease; Drug usage; Epidemic; Ethiopia; Focus Groups; Frequencies; Gender; Guidelines; HIV; HIV Infections; HIV Seropositivity; Habits; Immune; Individual; Infection; Intervention; Interview; Investigation; Life; Link; Mastication; Measures; Narcotics; Occupations; Opportunistic Infections; Outcome; Patients; Pattern; Pharmaceutical Preparations; Plant Roots; Play; Policy Maker; Population; Prevalence; Prevention strategy; Qualitative Methods; Questionnaires; Religion; Research; Risk Factors; Role; Sex Behavior; Sexual Partners; Surveys; T-Lymphocyte; Testing; Tobacco use; Unsafe Sex; Urine; aged; antiretroviral therapy; high risk sexual behavior; hookah; khat; prevent; programs; sex risk; social

DESCRIPTION (provided by applicant): Ethiopia has an explosive HIV/AIDS epidemic with an estimated prevalence of 3.5%. There has been recent evidence that khat (Catha edulis), a locally grown and widely used drug, is associated with sexual activity and unprotected sex. In addition, khat use may be associated with an increase in CD4 T cells in HIV negative individuals. The proposed research will be a cross-sectional survey in three voluntary testing centers located in Addis Ababa, Ethiopia. The main research aims for this study are (1) to describe the pattern of khat use among adult Voluntary Counseling and Testing (VCT) clients in Ethiopia, through qualitative methods, (2) to examine the association between khat use and HIV status among adult VCT clients in Ethiopia, and (3) to examine the association between frequent khat use and CD 4 T cells in HIV negative individuals, after controlling for tobacco use. In depth interviews and focus groups will be conducted in the first few months of the proposed study to guide the development of a questionnaire and address the first research question. This will be followed by survey implemented through face-to-face interviews with consenting subjects aged 18-44, utilizing the VCT centers. Urine and blood samples will also be collected to measure khat exposure and quantity CD4 T cells respectively. In Ethiopia, which has the 5th largest HIV infected population, it will be important to know how khat chewing habit is linked to the spread of the disease. The use of khat is widespread (30-50% prevalence) and it has deep roots in the social and cultural tradition of Ethiopia. Information from this study can aid HIV/AIDS policy makers and programs to address the habitual use of khat as part of intervention efforts in preventing the spread of the epidemic. The outcome of such an investigation will also enhance our understanding of how khat may play a role in determining CD4 T cell count in HIV negative individuals. Project Narrative: A better understanding of the association between khat use and HIV status can aid HIV/AIDS policy makers and programs to address khat use in preventing the spread of the epidemic. In addition, CD4 T cells have been used as a measure of immune status in individuals infected with HIV. Many of the immunological disturbances observed among patients infected with HIV are related to the decline in CD4 T cell counts and percentage during the course of infection; if among HIV positive individuals, khat chewers have a different CD 4 T cell profile than non- chewers, they may require different management guidelines for chemoprophylaxis of opportunistic infections or antiretroviral therapy.

描述（由申请人提供）：埃塞俄比亚艾滋病毒/艾滋病呈爆炸性流行，估计流行率为3.5%。最近有证据表明，阿拉伯茶（Catha edulis）是一种当地种植和广泛使用的药物，与性活动和无保护的性行为有关。此外，阿拉伯茶的使用可能与HIV阴性个体CD4 T细胞的增加有关。拟议的研究将在位于埃塞俄比亚亚的斯亚贝巴的三个自愿检测中心进行横断面调查。本研究的主要研究目的是：(1)通过定性方法描述埃塞俄比亚成人自愿咨询和检测（VCT）客户中阿拉伯茶的使用模式，(2)检查埃塞俄比亚成年VCT客户中阿拉伯茶使用与艾滋病毒状态之间的关系，以及(3)在控制烟草使用后，检查艾滋病毒阴性个体中频繁使用阿拉伯茶与cd4 T细胞之间的关系。在拟议研究的前几个月将进行深入访谈和焦点小组，以指导问卷的开发并解决第一个研究问题。随后将利用VCT中心对18-44岁的同意受试者进行面对面访谈。还将收集尿液和血液样本，分别测量阿拉伯茶暴露量和CD4 T细胞数量。埃塞俄比亚是艾滋病毒感染人口第五大国家，了解咀嚼阿拉伯茶的习惯与该疾病的传播之间的关系非常重要。阿拉伯茶的使用很广泛（30-50%的流行率），它深深植根于埃塞俄比亚的社会和文化传统。这项研究的信息可以帮助艾滋病毒/艾滋病政策制定者和方案解决习惯性使用阿拉伯茶的问题，作为预防流行病传播的干预努力的一部分。这样一项研究的结果也将增强我们对阿拉伯茶如何在确定HIV阴性个体的CD4 T细胞计数中发挥作用的理解。