INBRE RESEARCH CORE

INBRE研究核心

• 批准号: 7610184
• 负责人: ROBERTA Fishman COLMAN
• 金额: $ 126.89万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610184
• 关键词: 3-Dimensional; Agreement; Algorithms; American Association for the Advancement of Science; Apoptotic; Authorship; Biochemistry; Bioinformatics; Biological Models; Biological Sciences; Biology; Biomedical Research; Birds; Borrelia burgdorferi; Breast; Budgets; Cancer Detection; Caring; Cell model; Cells; Chalk; Charge; Chemistry; Collaborations; Collagen; Communities; Computer Retrieval of Information on Scientific Projects Database; Computers; DNA Sequence; Delaware; Development; Engineering; Evaluation; Faculty; Family; Fees; Funding; Gene Expression; Genetic Variation; Genotype; Glass; Goals; Grant; Healthcare Systems; Hepatic; Human; Image Analysis; Information Sciences; Institution; Invertebrates; Joints; Leadership; Learning; Lung; Lung Neoplasms; Lung diseases; Lyme Disease; Malignant Neoplasms; Malignant neoplasm of brain; Mass Spectrum Analysis; Mathematics; Melissa; Mentors; Microsporidia; Modeling; Nanotechnology; Neurobiology; Neurosciences; Pediatric Hospitals; Persons; Physics; Process; Production; Progress Reports; Proteins; Proteomics; Publications; Published Comment; RNA Caps; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; Science; Sensory Process; Source; Students; Suggestion; Surface; Testing; Therapeutic; Three-Dimensional Imaging; Three-dimensional analysis; Tick-Borne Diseases; Time; Title; Translational Research; United States National Institutes of Health; Universities; Update; Veronica; Visit; Work; androgen independent prostate cancer; anticancer research; autocrine; bioimaging; cancer cell; cohort; college; day; falls; human IGFBP2 protein; instrumentation; lipid metabolism; member; neoplastic; outreach; professor; programs; protein expression; scaffold; surfactant; virtual

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Delaware INBRE Annual Progress Report (APR) 2007 Grant No. 5P20RR016472-2007 Research Core Core Objective: Strengthen the biomedical research capability in the Delaware INBRE network, through pilot research grants, mentoring, and access to infrastructure. Overview The INBRE Research Core, through its Research Committee, is charged with providing guidance and research expertise to help the program meet its biomedical research goals. The committee is broadly representative of the state-wide institutions involved in the Delaware INBRE. In addition to Roberta F. Colman as Chair, the current members are: Brian Little and Nicholas Petrelli - Christiana Care Health System Beverly Hartline - Delaware State University Joan Barber and Sam Panella - Delaware Technical & Community College Vicky Funanage - Nemours Biomedical Research Abraham Lenhoff, Veronica Rempusheski, and Karl Steiner - University of Delaware Bette Coplan, Paul DeGategno, and Malcolm DSouza, and Jonathan Kidd - Wesley College The third year of INBRE research involved the start of a new cohort of INBRE grantees, whose research began June 1, 2006, shortly after the start of INBRE Year 3. New INBRE Researchers and Project Titles: University of Delaware: Six 32-month projects: Farach-Carson, M. Cynthia - Professor, Biological Sciences Electrospun Collagen Scaffolds for Development of 3-D Cellular Models for Testing Anti-Neoplastic Agents Galileo, Deni  Assistant Professor, Biological Sciences Autocrine Stimulation of Primary and Metastatic Brain Cancer Cells *(Project funded under the Christiana Care budget allocation) Johnston, Murray  Professor, Chemistry and Biochemistry Mason, Robert  Director, Cell Science Core, Nemours Proteomic Analysis of Apoptotic Mechanisms in Cancer Kambhamettu, Chandra  Associate Professor, Computer and Information Sciences 3-D Image Analysis Algorithms for Automatic Computation of Ground Glass Opacity of Lung Tumors Panchapakesan, Balaji - Assistant Professor, Electrical and Computer Engineering Nanotechnology for Cancer Detection and Therapeutics Sikes, Robert - Assistant Professor, Biological Sciences Role of IGFBP-2 Fragments in Development of Androgen Insensitive Prostate Cancer Delaware State University: Four 32-month projects (plus 1 continuing project): Besong, Samuel A.  Associate Professor, Family and Consumer Sciences Hepatic Lipid Metabolism and Gene Expression in Hen DiMaria, Peter - Associate Professor, Chemistry RNA Cap Hypermethylases in Microsporidia Harrington, Melissa  Associate Professor, Biology Davis, Leonard  Associate Professor, Biology Pokrajac, Dragoljub  Assistant Professor, Computer & Information Science Investigating the Neurobiology of Sensory Processing and Learning in an Invertebrate Model System Liu, Fengshan  Professor, Applied Mathematics and Theoretical Physics Analysis of 3-D Breast Surface Deformation during Mammographic Compression Sabrina Brougher  Assistant Professor, Biology *(Continuing Project) Characterization of Surfactant Protein Expression in Avian Lung as a Model for Upper Respiratory Disease in Humans AI DuPont Hospital for Children  Nemours Kreuger, Leslie J. Wesley College: Three one-year projects: D'Souza, Malcolm  Professor, Chemistry Extent of Nucleophilic Participation in Acyl, Sulfonyl and Sulfamoyl Halides Everett, Lynn  Associate Professor, Biology Genetic Diversity in Borrelia burgdorferi Kidd, Jonathan  Professor, Biology Curran, Kathleen  Associate Professor, Biology Distribution of Lyme Disease and Other Tick-borne Diseases in Delaware Research Meetings September and October 2006 EAB Meetings INBRE-funded researchers had the opportunity to present their research and talk with members of the INBRE External Advisory Board (EAB), the second time that the Board had an opportunity to meet network investigators in person. Faculty were asked to provide research summaries in advance of the meeting, and to provide a research update for the EAB the day of the meeting. This process allowed the EAB to focus on key questions for investigators work toward sustainability. The aim was to talk with investigators in a focused way to encourage steps toward R01 proposal submission by June 2008. EAB members offered suggestions during the meeting, and provided summary comments in their fall report, attached to this document. January 2007 AAAS Meeting As part of the Delaware INBRE evaluation process, a panel arranged through AAAS conducts an evaluation visit every second year. The January 2007 meeting constituted the second INBRE visit. The AAAS panel recognized progress made in the research network, and praised the INBRE leadership, research infrastructure, outreach and evaluation efforts to date. After meeting with INBRE investigators, the AAAS panel recommended adding more informal research meetings to the INBRE plan. Informal brown bags and chalk talks are now slated to begin in spring 2007. Christiana Care has established a new collaboration with Nemours Biomedical Research, where an active biomedical translational research program is in place. In Year 3, AI DuPont Hospital for Children - Nemours became a new partner in the Delaware INBRE, with Dr. Leslie J. Kreuger as a currently funded investigator. At Delaware State University (DSU), Dr. Melissa Harrington, an INBRE-funded researcher, has used the INBRE 'umbrella' to organize a statewide neuroscience network, which brings together faculty and students for seminars and for exploring and pursuing collaborative research ideas. Research and educational collaborations between DSU and nearby Wesley College are growing. One initiative underway is an agreement toward a joint degree program in biological chemistry. Work will continue on this joint program in 2007. INBRE funding at Wesley College, an undergraduate institution, allowed investigators to pursue summer research that involved undergraduate students, and which led to their participation in several national meetings, and student co-authorship on several publications. The Delaware INBRE continues to support investigators through core center fee waivers. Investigators in the INBRE Network were able to apply to use, at no charge, core instrumentation centers including Bioinformatics, Bioimaging, DNA Sequencing and Genotyping, Mass Spectroscopy, Microarray, NMR and Protein Production and Analysis. The Delaware INBRE contributed substantially to establishing a new Center for Translational Cancer Research (CTCR) in 2006. The CTCR will be launched as a virtual entity between UD, DBI, Christiana Care and Nemours. Dr. Cindy Farach-Carson, one of the new faculty in INBRE Year 3, will serve as CTCRs Founding Director, and recurring funds for CTCR have been provided by the Delaware legislature.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 特拉华州近交年度进度报告（4月）2007年 赠款号5P20RR016472-2007 研究核心 核心目标：通过试点研究赠款，指导和获得基础设施的途径，增强特拉华州近亲网络中的生物医学研究能力。 概述 通过其研究委员会，INBRE研究核心负责提供指导和研究专业知识，以帮助该计划实现其生物医学研究目标。 该委员会广泛地代表了特拉华州涉及的全州机构。 除了罗伯塔·科尔曼（Roberta F. Colman）担任主席外，现任成员还有： Brian Little和Nicholas Petrelli -Christiana Care Health System 贝弗利·哈特林 - 特拉华州立大学 琼·巴伯（Joan Barber）和萨姆·帕内拉（Sam Panella） - 特拉华州技术与社区学院 Vicky Funanage -Nemours生物医学研究 亚伯拉罕·伦霍夫（Abraham Lenhoff），Veronica Rempusheski和Karl Steiner-特拉华大学 Bette Coplan，Paul DeGategno和Malcolm D Souza和Jonathan Kidd-卫斯理学院 Inbre研究的第三年涉及新的Inbre授予者队列的开始，该研究的研究始于2006年6月1日，即INBRE 3年级开始后不久。 新的近亲研究人员和项目头衔： 特拉华大学：六个32个月的项目： Farach -Carson，M。Cynthia-生物科学教授 用于开发3-D细胞模型的电纺胶原支架，用于测试抗塑料 伽利略，丹尼生物科学助理教授 对原发性和转移性脑癌细胞的自分泌刺激 *（基督教护理预算分配资助的项目） 约翰斯顿，默里化学和生物化学教授 梅森，罗伯特（Robert）导演，细胞科学核心 癌症中凋亡机制的蛋白质组学分析 Chandra Chandra副教授Kambhamettu计算机和信息科学副教授 3-D图像分析算法，用于自动计算肺肿瘤的地面玻璃不透明度 Balaji Panchapakesan-癌症检测和治疗剂的电气和计算机工程纳米技术助理教授 锡克斯，罗伯特 - 生物科学助理教授 IGFBP-2片段在雄激素不敏感的前列腺癌发展中的作用 特拉华州立大学：四个32个月的项目（加1个持续项目）： 贝桑，塞缪尔·A·副教授，家庭和消费者科学 母鸡中的肝脂质代谢和基因表达 彼得·迪亚里亚（Dimaria） - 化学副教授 小孢子虫中的RNA帽高甲基酶 哈灵顿，梅利莎生物学副教授 戴维斯，伦纳德生物学副教授 Pokrajac，Dragoljub计算机与信息科学助理教授 研究无脊椎动物模型系统中感觉处理和学习的神经生物学 刘山教授刘的应用数学和理论物理学 分析乳房X线学压缩过程中3-D乳腺表面变形 Sabrina Brougher生物学助理教授 *（持续项目） 表征禽肺表面活性剂蛋白表达作为人类上呼吸道疾病的模型 AI Dupont儿童医院Nemours 克鲁格（Kreuger），莱斯利（Leslie J.） 卫斯理学院：三个一年的项目： D'Souza，Malcolm教授，化学教授 亲核参与酰基，磺酰基和磺胺卤化物的程度 埃弗里特（Everett），林恩（Lynn）生物学副教授 Borrelia Burgdorferi的遗传多样性 Kidd，乔纳森（Jonathan）教授，生物学 Curran，凯瑟琳生物学副教授 特拉华州的莱姆病和其他tick传播疾病的分布 研究会议 2006年9月和10月EAB会议 INBRE资助的研究人员有机会与Inbre外部顾问委员会（EAB）的成员进行研究并进行对话，这是董事会第二次有机会亲自与网络调查员会面。 要求教师在会议之前提供研究摘要，并在会议当天为EAB提供研究更新。 这一过程使EAB可以专注于研究人员致力于可持续性的关键问题。 目的是以一种重点与调查人员进行交谈，以鼓励到2008年6月提出R01提案的步骤。EAB成员在会议期间提出了建议，并在本文件附带的秋季报告中提供了摘要评论。 2007年1月AAAS会议 作为特拉华州近亲评估过程的一部分，通过AAAS安排的一个小组每隔第二年进行评估访问。 2007年1月的会议构成了第二次近亲访问。 AAAS小组认可了研究网络取得的进展，并赞扬了迄今为止的近亲领导力，研究基础设施，外展和评估工作。 在与Inbre调查人员会面后，AAAS小组建议在INBRE计划中添加更多非正式的研究会议。 现在，非正式的棕色袋子和粉笔谈话定于2007年春季开始。 克里斯蒂安娜（Christiana Care）与Nemours生物医学研究建立了新的合作，该研究正在制定活跃的生物医学转化研究计划。 在第三年，AI Dupont儿童医院 - Nemours成为特拉华州inbre的新合作伙伴，莱斯利·J·克鲁格（Leslie J. Kreuger）博士是当前资助的研究员。 在特拉华州立大学（DSU），INBRE资助的研究人员梅利莎·哈灵顿（Melissa Harrington）博士使用inbre的“伞”来组织一个全州的神经科学网络，该网络将教职员工和学生聚集在一起，进行研讨会，探索和追求协作研究思想。 DSU和附近卫斯理学院之间的研究和教育合作正在增长。 正在进行的一项倡议是一项关于生物化学联合学位计划的协议。 该联合计划将于2007年继续进行。 本科机构卫斯理学院的INBRE资金允许调查人员从事涉及本科生的夏季研究，并导致他们参加了几次全国性会议，并在几个出版物上合着学生。 特拉华州近亲继续通过核心中心费用豁免来支持调查人员。 Inbre网络中的研究人员能够无需使用核心仪器中心，包括生物信息学，生物成像，DNA测序和基因分型，质谱，微阵列，NMR，NMR以及蛋白质的产生以及分析。 特拉华州的近亲在2006年为建立新的转化癌症研究中心（CTCR）做出了重大贡献。CTCR将作为UD，DBI，Christiana Care和Nemours之间的虚拟实体推出。 辛迪·法拉赫·卡森（Cindy Farach-Carson）博士是INBRE 3年级的新学院之一，将担任CTCR的创始董事，并且由特拉华州立法机关提供了CTCR的经常性资金。