INBRE RESEARCH CORE

INBRE研究核心

• 批准号: 7381585
• 负责人: ROBERTA Fishman COLMAN
• 金额: $ 30.03万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381585
• 关键词: INBRE; RESEARCH; CORE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Delaware INBRE Annual Progress Report (APR) 2006 Grant No. 2P20RR016472-2006 Research Core Core Objective: Strengthen the biomedical research capability in the Delaware INBRE network, through pilot research grants, mentoring, and access to infrastructure. Overview Report of the INBRE Research Committee Dr. Roberta F. Colman, UD Chemistry and Biochemistry, Chair The INBRE Research Committee is charged with providing guidance and research expertise to help the program meet its biomedical research goals. The committee is broadly representative of the state-wide institutions involved in the Delaware INBRE. In addition to Roberta F. Colman as Chair, the current members are: Brian Little and Nicholas Petrelli - Christiana Care Health System Tommy Frederick and Gus Ofosu - Delaware State University Joan Barber and Ray Lynch - Delaware Technical & Community College Vicky Funanage - Nemours Biomedical Research Abraham Lenhoff, Lisa Plowfield, and Karl Steiner - University of Delaware Bette Coplan, Paul DeGategno, and Malcolm D¿Souza, and Jonathan Kidd - Wesley College The second year of INBRE research involved two broad categories of projects: 1.) The completion of two-year mentored research grants by currently funded faculty; and 2.) The selection of a new cohort of INBRE grantees, whose research will begin June 1, 2006, shortly after the start of INBRE Year 3. Currently funded Grantees Research Meetings ¿ Oct. 19-20, 2005 EAB Meeting and Poster Session INBRE-funded researchers had the opportunity to present their research and talk with members of the INBRE External Advisory Board (EAB), the first time that the Board had an opportunity to meet network investigators in person. Faculty also involved their graduate students and research associates in the presentation, and undergraduate researchers were invited in a separate, special session. These sessions were characterized by informal, stimulating discussions. March 27-28, 2006 EAB Meeting and Investigator Presentations The scheduled March 27-28 External Advisory Board meeting will feature two separate sessions for INBRE-funded researchers to present their work to the Board. On March 27, the new cohort of INBRE researchers will introduce their projects slated to begin on June 1, 2006. The next day, the currently funded group of investigators will present a summary of work undertaken, and will offer an analysis of their key products, accomplishments, and future directions. Accomplishments of currently funded researchers are detailed in the subproject reports in this document. The group of currently-funded researchers, all junior faculty in the early stages of their careers, were selected for INBRE participation in the spring of 2004. Their grants began in the fall of 2004, and will conclude in the spring of 2006. During this interval, among the five investigators at the more research-intensive University of Delaware, one investigator received an R01, two investigators participated as Co-PIs on COBRE, two investigators received NSF CAREER awards, and one member of the group is PI on three additional NSF grants. Three of the five appear to have good traction toward independence. Two of the five continue to submit proposals toward support for their research areas. During the same period, one INBRE-funded investigator at Delaware State University (DSU) was awarded an NSF RUI with a focus on virology research. Also at DSU, one INBRE-funded investigator accepted a position at another university, and funds for that project have been redirected to a new junior faculty member, with approval from the INBRE EAB and NCRR. A third INBRE-funded investigator had to stop his program in year two due to illness; funds will be reassigned by the INBRE PI. At Christiana Care one investigator has been very actively involved in collaborations with UD and DBI researchers. These collaborations have led to several presentations and one publication. A second investigator decided to leave the INBRE research program due to pregnancy and childbirth. A third investigator accepted a position at another medical center outside the State of Delaware. Some of the funds freed up by these departures have been re-directed to establish a new collaboration with Nemours Biomedical Research, where an active biomedical translational research program is in place. In Year 3, Nemours will be a new partner in the Delaware INBRE. INBRE funding at Wesley College, an undergraduate institution, allowed investigators to pursue summer research that involved undergraduate students, and which led to their participation in several national meetings, and student co-authorship on one publication. Although the direct funding of this first phase of research projects will conclude in June 2006, the Delaware INBRE will continue to support investigators through core center fee waivers. Investigators in the INBRE Network may arrange to use, at no charge, core instrumentation centers including Bioinformatics, Bioimaging, DNA Sequencing and Genotyping, Mass Spectroscopy, Microarray, NMR and Protein Production and Analysis. New Delaware INBRE research solicitation The Delaware INBRE research and administrative leadership recognized an important opportunity to place a sharper research focus for grants provided to researchers in the next three years of the program. The new focus, on basic and translational work in cancer, builds on strengths at the University of Delaware, and the interests of the Helen F. Graham Cancer Center at INBRE partner Christiana Care Health System and at Nemours Biomedical Research. The new focus did not eliminate consideration of other types of basic research, but instead offered some common ground upon which to build a more cohesive community among INBRE investigators. In addition, the decision was made to open the call for proposals to both junior and senior investigators. This approach will lead to a stronger group of faculty researchers who can build close collaborations and benefit from each other within the broader goal of establishing a growing biomedical research capability in Delaware. A new round of INBRE-funded grants was announced in October 2005, and the announcements were circulated to Deans and Chairs among Delaware INBRE partners for distribution broadly to faculty. The INBRE RFP, instructions and forms were posted on the DBI website, and DBI staff responded to questions as needed. The new round of INBRE grants was designed to be similar to an NIH R03 in intent, and provided $160k in direct costs over a period of 32 months. Proposals were submitted in December 2005. The INBRE research committee reviewed and scored the 31 proposals submitted. Reviewers used the following set of weighted criteria to score each proposal: ¿ Scientific/ biomedical merit 50% ¿ Contribution to the Delaware cancer initiative. 15% ¿ Undergraduate involvement 10% ¿ Interdisciplinary component. 10% ¿ Inter-institutional component 5% ¿ Use of core centers 5% ¿ Potential to lead to an NIH grant application 5% In January 2006, the committee¿s recommended 13 choices were sent to the EAB for review and approval. In February 2006, the EAB completed the approval process. Based on its experience in the INBRE program during Years 1 & 2, Christiana Care decided that it could best contribute to and benefit from the INBRE program objectives by using some of its funding to support a program at Nemours Biomedical Research and to support one of the junior faculty members at the University of Delaware whose research closely matches the cancer focus of the Helen F. Graham, Cancer Center. Dr. Nicholas Petrelli, Medical Director of the Cancer Center, will serve as the mentor for this project, conducted by Dr. Deni Galileo, and Assistant Professor at the University of Delaware¿s Department of Biological Sciences. This collaboration fits well into a larger plan to establish a Center for Translational Cancer Research (CTCR). The CTCR will be launched as a virtual entity between UD, DBI, Christiana Care and Nemours. Dr. Cindy Farach-Carson, one of the new faculty in INBRE Year 3, will serve as CTCR¿s Founding Director, and recurring funds for CTCR have been included in the Governor¿s budget request for 2007. New INBRE Researchers and Project Titles: University of Delaware: Six 32-month projects: Farach-Carson, M. Cynthia - Professor, Biological Sciences Electrospun Collagen Scaffolds for Development of 3-D Cellular Models for Testing Anti-Neoplastic Agents Galileo, Deni ¿ Assistant Professor, Biological Sciences Autocrine Stimulation of Primary and Metastatic Brain Cancer Cells *(Project funded under the Christiana Care budget allocation) Johnston, Murray ¿ Professor, Chemistry and Biochemistry Mason, Robert ¿ Director, Cell Science Core, Nemours Proteomic Analysis of Apoptotic Mechanisms in Cancer Kambhamettu, Chandra ¿ Associate Professor, Computer and Information Sciences 3-D Image Analysis Algorithms for Automatic Computation of Ground Glass Opacity of Lung Tumors Panchapakesan, Balaji - Assistant Professor, Electrical and Computer Engineering Nanotechnology for Cancer Detection and Therapeutics Sikes, Robert - Assistant Professor, Biological Sciences Role of IGFBP-2 Fragments in Development of Androgen Insensitive Prostate Cancer Delaware State University: Four 32-month projects (plus 1 continuing project): Besong, Samuel A. ¿ Associate Professor, Family and Consumer Sciences Hepatic Lipid Metabolism and Gene Expression in Hen DiMaria, Peter - Associate Professor, Chemistry RNA Cap Hypermethylases in Microsporidia Harrington, Melissa ¿ Associate Professor, Biology Davis, Leonard ¿ Associate Professor, Biology Pokrajac, Dragoljub ¿ Assistant Professor, Computer & Information Science Investigating the Neurobiology of Sensory Processing and Learning in an Invertebrate Model System Liu, Fengshan ¿ Professor, Applied Mathematics and Theoretical Physics Analysis of 3-D Breast Surface Deformation during Mammographic Compression Sabrina Brougher ¿ Assistant Professor, Biology *(Continuing Project) Characterization of Surfactant Protein Expression in Avian Lung as a Model for Upper Respiratory Disease in Humans Wesley College: Three one-year projects: D'Souza, Malcolm ¿ Professor, Chemistry Extent of Nucleophilic Participation in Acyl, Sulfonyl and Sulfamoyl Halides Everett, Lynn ¿ Associate Professor, Biology Genetic Diversity in Borrelia burgdorferi Kidd, Jonathan ¿ Professor, Biology Curran, Kathleen ¿ Associate Professor, Biology Distribution of Lyme Disease and Other Tick-borne Diseases in Del

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。特拉华州INBRE年度进展报告（APR） 2006拨款号2P20RR016472-2006研究核心核心目标：通过试点研究资助、指导和获得基础设施，加强特拉华州INBRE网络的生物医学研究能力。博士Roberta F. Colman， UD化学和生物化学主席，INBRE研究委员会负责提供指导和研究专业知识，以帮助该计划实现其生物医学研究目标。该委员会广泛代表了参与特拉华州INBRE的全州机构。除了罗伯塔·科尔曼（Roberta F. Colman）担任主席外，目前的成员包括：Brian Little和Nicholas Petrelli - Christiana Care Health System Tommy Frederick和Gus Ofosu -特拉华州立大学Joan Barber和Ray Lynch -特拉华技术和社区学院Vicky Funanage - Nemours生物医学研究Abraham Lenhoff， Lisa Plowfield和Karl Steiner -特拉华大学Bette Coplan， Paul DeGategno, and Malcolm D¿Souza， and Jonathan Kidd - Wesley College INBRE研究的第二年涉及两大类项目：获资助教师完成为期两年的研究资助；和2)。选择一批新的受资助人，他们的研究将于2006年6月1日开始，在INBRE第三年开始后不久。2005年10月19日至20日，INBRE资助的研究人员有机会展示他们的研究成果，并与INBRE外部咨询委员会（EAB）的成员交谈，这是该委员会第一次有机会亲自与网络调查人员会面。教师们也让他们的研究生和研究助理参加了报告，本科生研究人员也被邀请参加了一个单独的特别会议。这些会议的特点是非正式的、激励性的讨论。2006年3月27-28日EAB会议和研究者报告预定于3月27-28日召开的外部咨询委员会会议将分为两部分，由inbre资助的研究人员向委员会介绍他们的工作。3月27日，新一批INBRE研究人员将介绍他们计划于2006年6月1日开始的项目。第二天，目前获得资助的研究小组将对所开展的工作进行总结，并对他们的主要产品、成就和未来方向进行分析。在本文件的子项目报告中详细介绍了目前资助的研究人员的成就。目前获得资助的研究人员都是处于职业生涯早期阶段的初级教师，他们于2004年春季被选中参加INBRE的研究。他们的资助从2004年秋季开始，将于2006年春季结束。在此期间，在研究更密集的特拉华大学的五名研究人员中，一名研究人员获得了R01，两名研究人员作为COBRE的共同PI参与，两名研究人员获得了NSF CAREER奖，该小组的一名成员是另外三项NSF资助的PI。这5个国家中有3个似乎在独立方面有良好的吸引力。五人中有两人继续提交提案，以支持他们的研究领域。在同一时期，特拉华州立大学（DSU）的一名inbre资助的研究人员获得了美国国家科学基金会（NSF）的RUI，重点是病毒学研究。同样在DSU，一名INBRE资助的研究者接受了另一所大学的职位，该项目的资金已重新定向给一名新的初级教员，并得到了INBRE EAB和NCRR的批准。第三位由inbre资助的研究者在第二年因病不得不停止他的项目；资金将由INBRE PI重新分配。在克里斯蒂安娜护理中心，一名研究人员非常积极地参与了与特拉华大学和DBI研究人员的合作。这些合作导致了几次演讲和一份出版物。第二名研究者因怀孕和分娩决定离开INBRE的研究项目。第三名调查员接受了特拉华州以外的另一家医疗中心的职位。这些离职腾出的一些资金已被重新用于与Nemours生物医学研究中心建立新的合作关系，该中心正在开展积极的生物医学转化研究项目。在第三年，Nemours将成为特拉华州INBRE的新合作伙伴。卫斯理学院（Wesley College）是一所本科院校，INBRE资助了调查人员，使他们能够进行有本科生参与的暑期研究，这导致他们参加了几次全国性会议，并在一份出版物上与学生合作。尽管第一阶段研究项目的直接资助将于2006年6月结束，特拉华州INBRE将继续通过核心中心的费用减免来支持研究人员。INBRE网络的研究人员可以免费安排使用核心仪器中心，包括生物信息学、生物成像、DNA测序和基因分型、质谱、微阵列、核磁共振和蛋白质生产和分析。特拉华州INBRE研究和行政领导认识到一个重要的机会，在未来三年的计划中，为研究人员提供更清晰的研究重点。新的重点是癌症的基础和转化工作，建立在特拉华大学的优势，以及INBRE合作伙伴Christiana Care Health System的Helen F. Graham癌症中心和Nemours生物医学研究的利益之上。新的重点并没有消除对其他类型基础研究的考虑，而是提供了一些共同点，以在INBRE研究人员之间建立一个更有凝聚力的社区。此外，还决定向初级和高级调查人员开放征求建议。这种方法将导致一个更强大的教师研究小组，他们可以在特拉华州建立一个不断增长的生物医学研究能力的更广泛的目标中建立密切的合作和相互受益。2005年10月宣布了新一轮INBRE资助的补助金，并将公告分发给特拉华州INBRE合作伙伴的院长和主席，以便广泛分发给教职员工。INBRE的RFP、说明和表格发布在DBI网站上，DBI工作人员根据需要回答问题。新一轮INBRE拨款的设计意图类似于NIH R03，并在32个月的时间内提供16万美元的直接费用。建议已于2005年12月提交。INBRE研究委员会对提交的31份提案进行了审查并打分。审稿人使用以下加权标准对每个提案进行评分：科学/生物医学价值50%对特拉华州癌症倡议的贡献。15%本科生参与10%跨学科成分。2006年1月，委员会推荐的13个选择被送到EAB进行审查和批准。2006年2月，监管局完成了审批程序。基于第一年和第二年在INBRE项目中的经验，Christiana Care决定，通过使用一些资金来支持Nemours生物医学研究项目，并支持特拉华大学的一名初级教师，他的研究与海伦·f·格雷厄姆癌症中心的癌症研究密切相关，从而为INBRE项目目标做出最好的贡献并从中受益。癌症中心医学主任Nicholas Petrelli博士将担任该项目的导师，由特拉华大学生物科学系助理教授Deni Galileo博士负责。这项合作与建立转化性癌症研究中心（CTCR）的更大计划非常契合。CTCR将作为UD、DBI、Christiana Care和Nemours之间的虚拟实体推出。INBRE三年级的一位新教师Cindy Farach-Carson博士将担任CTCR的创始主任，CTCR的经常性资金已列入2007年总督的预算申请。新INBRE研究员和项目头衔：特拉华大学：6个32个月的项目；Farach-Carson， M. Cynthia -生物科学教授，用于测试抗肿瘤药物的3-D细胞模型开发的电纺丝胶原蛋白支架伽利略，生物科学助理教授，原发性和转移性脑癌细胞的自分泌刺激*（项目由Christiana Care预算拨款资助）Johnston， Murray教授，化学和生物化学Mason， Robert¿主任，细胞科学核心，肺癌细胞凋亡机制的Nemours蛋白质组学分析Kambhamettu，钱德拉副教授，计算机与信息科学，肺肿瘤磨玻璃透明度自动计算的三维图像分析算法Panchapakesan， Balaji -助理教授，电子与计算机工程纳米技术用于癌症检测和治疗学，Robert -助理教授IGFBP-2片段在雄激素不敏感前列腺癌发展中的生物学作用特拉华州立大学：四个32个月的项目（加一个正在进行的项目）Besong, Samuel A.¿副教授，家庭和消费者科学，肝脂质代谢和基因表达在Hen DiMaria， Peter -副教授，化学RNA帽超甲基化酶在微孢子虫哈林顿，Melissa¿副教授，生物学Davis， Leonard¿副教授，生物学Pokrajac， Dragoljub¿助理教授，计算机与信息科学，研究无脊椎动物模型系统中感觉加工和学习的神经生物学教授，应用数学和理论物理乳腺x线摄影压缩过程中乳腺表面三维变形的分析Sabrina Brougher教授，生物学助理教授*（正在进行的项目）禽肺表面活性蛋白表达作为人类上呼吸道疾病模型的表征D'Souza， Malcolm教授，酰基、磺酰基和磺胺酰卤类亲核参与的化学程度Everett， Lynn副教授，伯氏疏螺旋体基德的生物学遗传多样性，Jonathan教授，生物学Curran， Kathleen副教授，莱姆病和其他蜱传疾病在德尔的生物学分布