INBRE RESEARCH CORE

INBRE研究核心

• 批准号: 7381585
• 负责人: ROBERTA Fishman COLMAN
• 金额: $ 30.03万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381585
• 关键词: INBRE; RESEARCH; CORE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Delaware INBRE Annual Progress Report (APR) 2006 Grant No. 2P20RR016472-2006 Research Core Core Objective: Strengthen the biomedical research capability in the Delaware INBRE network, through pilot research grants, mentoring, and access to infrastructure. Overview Report of the INBRE Research Committee Dr. Roberta F. Colman, UD Chemistry and Biochemistry, Chair The INBRE Research Committee is charged with providing guidance and research expertise to help the program meet its biomedical research goals. The committee is broadly representative of the state-wide institutions involved in the Delaware INBRE. In addition to Roberta F. Colman as Chair, the current members are: Brian Little and Nicholas Petrelli - Christiana Care Health System Tommy Frederick and Gus Ofosu - Delaware State University Joan Barber and Ray Lynch - Delaware Technical & Community College Vicky Funanage - Nemours Biomedical Research Abraham Lenhoff, Lisa Plowfield, and Karl Steiner - University of Delaware Bette Coplan, Paul DeGategno, and Malcolm D¿Souza, and Jonathan Kidd - Wesley College The second year of INBRE research involved two broad categories of projects: 1.) The completion of two-year mentored research grants by currently funded faculty; and 2.) The selection of a new cohort of INBRE grantees, whose research will begin June 1, 2006, shortly after the start of INBRE Year 3. Currently funded Grantees Research Meetings ¿ Oct. 19-20, 2005 EAB Meeting and Poster Session INBRE-funded researchers had the opportunity to present their research and talk with members of the INBRE External Advisory Board (EAB), the first time that the Board had an opportunity to meet network investigators in person. Faculty also involved their graduate students and research associates in the presentation, and undergraduate researchers were invited in a separate, special session. These sessions were characterized by informal, stimulating discussions. March 27-28, 2006 EAB Meeting and Investigator Presentations The scheduled March 27-28 External Advisory Board meeting will feature two separate sessions for INBRE-funded researchers to present their work to the Board. On March 27, the new cohort of INBRE researchers will introduce their projects slated to begin on June 1, 2006. The next day, the currently funded group of investigators will present a summary of work undertaken, and will offer an analysis of their key products, accomplishments, and future directions. Accomplishments of currently funded researchers are detailed in the subproject reports in this document. The group of currently-funded researchers, all junior faculty in the early stages of their careers, were selected for INBRE participation in the spring of 2004. Their grants began in the fall of 2004, and will conclude in the spring of 2006. During this interval, among the five investigators at the more research-intensive University of Delaware, one investigator received an R01, two investigators participated as Co-PIs on COBRE, two investigators received NSF CAREER awards, and one member of the group is PI on three additional NSF grants. Three of the five appear to have good traction toward independence. Two of the five continue to submit proposals toward support for their research areas. During the same period, one INBRE-funded investigator at Delaware State University (DSU) was awarded an NSF RUI with a focus on virology research. Also at DSU, one INBRE-funded investigator accepted a position at another university, and funds for that project have been redirected to a new junior faculty member, with approval from the INBRE EAB and NCRR. A third INBRE-funded investigator had to stop his program in year two due to illness; funds will be reassigned by the INBRE PI. At Christiana Care one investigator has been very actively involved in collaborations with UD and DBI researchers. These collaborations have led to several presentations and one publication. A second investigator decided to leave the INBRE research program due to pregnancy and childbirth. A third investigator accepted a position at another medical center outside the State of Delaware. Some of the funds freed up by these departures have been re-directed to establish a new collaboration with Nemours Biomedical Research, where an active biomedical translational research program is in place. In Year 3, Nemours will be a new partner in the Delaware INBRE. INBRE funding at Wesley College, an undergraduate institution, allowed investigators to pursue summer research that involved undergraduate students, and which led to their participation in several national meetings, and student co-authorship on one publication. Although the direct funding of this first phase of research projects will conclude in June 2006, the Delaware INBRE will continue to support investigators through core center fee waivers. Investigators in the INBRE Network may arrange to use, at no charge, core instrumentation centers including Bioinformatics, Bioimaging, DNA Sequencing and Genotyping, Mass Spectroscopy, Microarray, NMR and Protein Production and Analysis. New Delaware INBRE research solicitation The Delaware INBRE research and administrative leadership recognized an important opportunity to place a sharper research focus for grants provided to researchers in the next three years of the program. The new focus, on basic and translational work in cancer, builds on strengths at the University of Delaware, and the interests of the Helen F. Graham Cancer Center at INBRE partner Christiana Care Health System and at Nemours Biomedical Research. The new focus did not eliminate consideration of other types of basic research, but instead offered some common ground upon which to build a more cohesive community among INBRE investigators. In addition, the decision was made to open the call for proposals to both junior and senior investigators. This approach will lead to a stronger group of faculty researchers who can build close collaborations and benefit from each other within the broader goal of establishing a growing biomedical research capability in Delaware. A new round of INBRE-funded grants was announced in October 2005, and the announcements were circulated to Deans and Chairs among Delaware INBRE partners for distribution broadly to faculty. The INBRE RFP, instructions and forms were posted on the DBI website, and DBI staff responded to questions as needed. The new round of INBRE grants was designed to be similar to an NIH R03 in intent, and provided $160k in direct costs over a period of 32 months. Proposals were submitted in December 2005. The INBRE research committee reviewed and scored the 31 proposals submitted. Reviewers used the following set of weighted criteria to score each proposal: ¿ Scientific/ biomedical merit 50% ¿ Contribution to the Delaware cancer initiative. 15% ¿ Undergraduate involvement 10% ¿ Interdisciplinary component. 10% ¿ Inter-institutional component 5% ¿ Use of core centers 5% ¿ Potential to lead to an NIH grant application 5% In January 2006, the committee¿s recommended 13 choices were sent to the EAB for review and approval. In February 2006, the EAB completed the approval process. Based on its experience in the INBRE program during Years 1 & 2, Christiana Care decided that it could best contribute to and benefit from the INBRE program objectives by using some of its funding to support a program at Nemours Biomedical Research and to support one of the junior faculty members at the University of Delaware whose research closely matches the cancer focus of the Helen F. Graham, Cancer Center. Dr. Nicholas Petrelli, Medical Director of the Cancer Center, will serve as the mentor for this project, conducted by Dr. Deni Galileo, and Assistant Professor at the University of Delaware¿s Department of Biological Sciences. This collaboration fits well into a larger plan to establish a Center for Translational Cancer Research (CTCR). The CTCR will be launched as a virtual entity between UD, DBI, Christiana Care and Nemours. Dr. Cindy Farach-Carson, one of the new faculty in INBRE Year 3, will serve as CTCR¿s Founding Director, and recurring funds for CTCR have been included in the Governor¿s budget request for 2007. New INBRE Researchers and Project Titles: University of Delaware: Six 32-month projects: Farach-Carson, M. Cynthia - Professor, Biological Sciences Electrospun Collagen Scaffolds for Development of 3-D Cellular Models for Testing Anti-Neoplastic Agents Galileo, Deni ¿ Assistant Professor, Biological Sciences Autocrine Stimulation of Primary and Metastatic Brain Cancer Cells *(Project funded under the Christiana Care budget allocation) Johnston, Murray ¿ Professor, Chemistry and Biochemistry Mason, Robert ¿ Director, Cell Science Core, Nemours Proteomic Analysis of Apoptotic Mechanisms in Cancer Kambhamettu, Chandra ¿ Associate Professor, Computer and Information Sciences 3-D Image Analysis Algorithms for Automatic Computation of Ground Glass Opacity of Lung Tumors Panchapakesan, Balaji - Assistant Professor, Electrical and Computer Engineering Nanotechnology for Cancer Detection and Therapeutics Sikes, Robert - Assistant Professor, Biological Sciences Role of IGFBP-2 Fragments in Development of Androgen Insensitive Prostate Cancer Delaware State University: Four 32-month projects (plus 1 continuing project): Besong, Samuel A. ¿ Associate Professor, Family and Consumer Sciences Hepatic Lipid Metabolism and Gene Expression in Hen DiMaria, Peter - Associate Professor, Chemistry RNA Cap Hypermethylases in Microsporidia Harrington, Melissa ¿ Associate Professor, Biology Davis, Leonard ¿ Associate Professor, Biology Pokrajac, Dragoljub ¿ Assistant Professor, Computer & Information Science Investigating the Neurobiology of Sensory Processing and Learning in an Invertebrate Model System Liu, Fengshan ¿ Professor, Applied Mathematics and Theoretical Physics Analysis of 3-D Breast Surface Deformation during Mammographic Compression Sabrina Brougher ¿ Assistant Professor, Biology *(Continuing Project) Characterization of Surfactant Protein Expression in Avian Lung as a Model for Upper Respiratory Disease in Humans Wesley College: Three one-year projects: D'Souza, Malcolm ¿ Professor, Chemistry Extent of Nucleophilic Participation in Acyl, Sulfonyl and Sulfamoyl Halides Everett, Lynn ¿ Associate Professor, Biology Genetic Diversity in Borrelia burgdorferi Kidd, Jonathan ¿ Professor, Biology Curran, Kathleen ¿ Associate Professor, Biology Distribution of Lyme Disease and Other Tick-borne Diseases in Del

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。特拉华州 INBRE 年度进展报告 (APR) 2006 拨款编号 2P20RR016472-2006 研究核心 核心目标：通过试点研究拨款、指导和基础设施的使用，加强特拉华州 INBRE 网络的生物医学研究能力。 INBRE 研究委员会概述报告 特拉华大学化学与生物化学主席 Roberta F. Colman 博士 INBRE 研究委员会负责提供指导和研究专业知识，帮助该项目实现其生物医学研究目标。该委员会广泛代表参与特拉华州 INBRE 的全州机构。除了担任主席的 Roberta F. Colman 之外，现任成员包括： Brian Little 和 Nicholas Petrelli - Christiana Care Health System Tommy Frederick 和 Gus Ofosu - 特拉华州立大学 Joan Barber 和 Ray Lynch - 特拉华技术与社区学院 Vicky Funanage - Nemours 生物医学研究 Abraham Lenhoff、Lisa Plowfield 和 Karl Steiner - 特拉华大学 Bette Coplan、Paul DeGategno、Malcolm D¿Souza 和 Jonathan Kidd - 韦斯利学院 INBRE 研究的第二年涉及两大类项目： 1.) 由当前资助的教师完成为期两年的指导研究资助； 2.) 选择一批新的 INBRE 受资助者，他们的研究将于 2006 年 6 月 1 日开始，即 INBRE 第 3 年开始后不久。 目前受资助的受资助者研究会议 ¿ 2005 年 10 月 19 日至 20 日 EAB 会议和海报会议 INBRE 资助的研究人员有机会展示他们的研究成果并与 INBRE 外部顾问委员会 (EAB) 成员进行交谈，这是委员会第一次有机会亲自会见网络调查人员。教师们还邀请了他们的研究生和研究助理参加了演讲，本科生研究人员也被邀请参加一个单独的特别会议。这些会议的特点是非正式的、富有启发性的讨论。 2006 年 3 月 27 日至 28 日 EAB 会议和研究者演示 定于 3 月 27 日至 28 日举行的外部顾问委员会会议将有两场单独的会议，供 INBRE 资助的研究人员向委员会介绍他们的工作。 3 月 27 日，新一批 INBRE 研究人员将介绍他们定于 2006 年 6 月 1 日开始的项目。第二天，目前获得资助的研究人员小组将总结所开展的工作，并对他们的主要产品、成就和未来方向进行分析。本文件的子项目报告详细介绍了当前受资助研究人员的成就。 目前受资助的研究人员群体全部是处于职业生涯早期阶段的初级教师，于 2004 年春季被选为参与 INBRE。他们的资助开始于 2004 年秋季，并将于 2006 年春季结束。在此期间，在研究更加密集的特拉华大学的五名研究人员中，一名研究人员获得了 R01，两名研究人员作为 COBRE 的联合 PI 参与，两名研究人员获得了 NSF职业生涯 奖项，该小组的一名成员是另外三项 NSF 拨款的 PI。五人中的三人似乎对独立有很大的吸引力。五人中的两人继续提交支持其研究领域的提案。同一时期，特拉华州立大学 (DSU) 的一名 INBRE 资助的研究人员获得了 NSF RUI，专注于病毒学研究。同样在 DSU，一名 INBRE 资助的研究人员接受了另一所大学的职位，经 INBRE EAB 和 NCRR 批准，该项目的资金已重新分配给一名新的初级教员。第三位 INBRE 资助的研究人员因病不得不在第二年停止他的项目；资金将由 INBRE PI 重新分配。 Christiana Care 的一名研究人员一直非常积极地参与与 UD 和 DBI 研究人员的合作。这些合作带来了多场演讲和一份出版物。第二位研究人员因怀孕和分娩而决定退出 INBRE 研究项目。第三名调查员接受了特拉华州以外另一家医疗中心的职位。这些离职所释放的部分资金已重新用于与内穆尔生物医学研究中心建立新的合作关系，该研究中心正在实施一项积极的生物医学转化研究计划。第三年，Nemours 将成为特拉华州 INBRE 的新合作伙伴。 韦斯利学院 (Wesley College) 的 INBRE 资助使研究人员能够开展涉及本科生的夏季研究，这使他们参加了多次全国性会议，并由学生共同撰写了一份出版物。 尽管第一阶段研究项目的直接资助将于 2006 年 6 月结束，但特拉华州 INBRE 将继续通过核心中心费用减免来支持研究人员。 INBRE 网络的研究人员可以免费安排使用核心仪器中心，包括生物信息学、生物成像、DNA 测序和基因分型、质谱、微阵列、核磁共振以及蛋白质生产和分析。 新的特拉华州 INBRE 研究征集 特拉华州 INBRE 研究和行政领导层认识到这是一个重要的机会，可以在该计划的未来三年内为研究人员提供更明确的研究重点。新的重点是癌症的基础和转化工作，建立在特拉华大学的优势以及 INBRE 合作伙伴 Christiana Care Health System 和 Nemours 生物医学研究的 Helen F. Graham 癌症中心的兴趣之上。新的重点并没有消除对其他类型基础研究的考虑，而是提供了一些共同点，在此基础上在 INBRE 研究人员之间建立更具凝聚力的社区。 此外，还决定向初级和高级研究人员开放提案征集。这种方法将导致一支更强大的教师研究人员队伍，他们可以在特拉华州建立不断增长的生物医学研究能力的更广泛目标中建立密切的合作并相互受益。 2005 年 10 月宣布了新一轮 INBRE 资助的拨款，该公告已分发给特拉华州 INBRE 合作伙伴的院长和主席，以便广泛分发给教师。 INBRE RFP、说明和表格已发布在 DBI 网站上，DBI 工作人员根据需要回答问题。新一轮 INBRE 拨款的设计意图与 NIH R03 类似，在 32 个月内提供 16 万美元的直接成本。提案于 2005 年 12 月提交。INBRE 研究委员会对提交的 31 项提案进行了审查和评分。评审员使用以下一组加权标准对每个提案进行评分： ¿ 科学/生物医学价值 50% ¿ 对特拉华州癌症倡议的贡献。 15% ¿ 本科生参与 10% ¿ 跨学科组成部分。 10% ¿ 机构间组成部分 5% ¿ 使用核心中心 5% ¿ 可能导致 NIH 拨款申请 5% 2006 年 1 月，委员会推荐的 13 个选择被发送给 EAB 进行审查和批准。 2006年2月，EAB完成了审批程序。 根据第一年和第二年在 INBRE 项目中的经验，Christiana Care 认为，它可以利用部分资金支持 Nemours 生物医学研究项目，并支持特拉华大学的一名初级教员，该教员的研究与 Helen F. Graham 癌症中心的癌症重点密切相关，从而最好地为 INBRE 项目目标做出贡献并从中受益。癌症中心医学主任 Nicholas Petrelli 博士将担任该项目的导师，该项目由特拉华大学生物科学系助理教授 Deni Galileo 博士主持。此次合作非常适合建立转化癌症研究中心 (CTCR) 的更大计划。 CTCR 将作为 UD、DBI、Christiana Care 和 Nemours 之间的虚拟实体推出。 Cindy Farach-Carson 博士是 INBRE 三年级的新教师之一，将担任 CTCR 的创始主任，CTCR 的经常性资金已包含在州长 2007 年的预算请求中。新的 INBRE 研究人员和项目名称：特拉华大学：六个为期 32 个月的项目：Farach-Carson、M. Cynthia - 生物科学静电纺胶原支架开发教授 用于测试抗肿瘤药物的 3-D 细胞模型 Galileo, Deni ¿ 生物科学助理教授，原发性和转移性脑癌细胞的自分泌刺激*（由 Christiana Care 预算拨款资助的项目） Johnston, Murray ¿ 化学和生物化学教授 Mason, Robert ¿ 细胞科学核心主任，癌症细胞凋亡机制的 Nemours 蛋白质组学分析 Kambhamettu, Chandra ¿ 计算机和信息科学副教授 用于自动计算肺肿瘤毛玻璃不透明度的 3-D 图像分析算法 Panchapakesan, Balaji - 助理教授，电气和计算机工程 用于癌症检测和治疗的纳米技术 Sikes, Robert - 生物科学助理教授 IGFBP-2 片段在雄激素不敏感发展中的作用 前列腺癌 特拉华州立大学：四个为期 32 个月的项目（加上 1 个持续项目）：Besong, Samuel A. ¿ 副教授，家庭和消费者科学 Hen DiMaria, Peter 的肝脂质代谢和基因表达 - 副教授，小孢子虫 RNA 帽高甲基化酶化学副教授 Harrington, Melissa ¿ 生物学副教授 Davis, Leonard ¿ 生物学教授 Pokrajac, Dragoljub ¿ 计算机与信息科学助理教授，研究无脊椎动物模型系统中感觉处理和学习的神经生物学 Liu, Fengshan ¿ 教授，应用数学和理论物理分析乳腺 X 线摄影压缩期间 3-D 乳房表面变形 Sabrina Brougher ¿ 生物学助理教授 *（持续项目）表面活性剂蛋白的表征 禽肺表达作为人类上呼吸道疾病的模型 韦斯利学院：三个一年期项目：D'Souza，Malcolm ¿ 教授，酰基、磺酰基和磺酰卤化物中亲核参与的化学程度 Everett, Lynn ¿ 副教授，伯氏疏螺旋体的生物遗传多样性 Kidd，Jonathan ¿ 教授，生物学 Curran， 凯瑟琳·德尔莱姆病和其他蜱传疾病的生物学分布副教授