DATA ACQUISITION, ANALYSIS AND MANAGEMENT CORE

目标 根据NIH关于PO1的指导方针，数据核心被设计为“一种服务或资源 因此不是为了提出研究问题而设计的。这个核心的目标是保持， 实施并为数据采集、统计分析和数据提供质量控制和最终用户支持 演示文稿。这些目标通过以下方式实现： 1.动物信息管理 2.数据采集硬件、软件和电子支持 3.组织清点和档案管理 4.集中数据分析、展示和数据归档 5.基于互联网的共享和分发 此外，数据核心还可提供以下方面的设计、制造、实施和维护支持 在每个项目中提出的活体实验中使用的采集子系统。 圣安东尼奥的怀孕和新生儿研究中心(CPNR)目前有一项数据采集， 多年来一直作为核心成功运作的计算和统计小组。尼克兰博士，詹金斯女士 和谢先生一直致力于为通过该应用程序续订的PO1提供类似的核心功能。 此外，该团队成员在5年内同时为两个PO1补助金提供核心服务 过去的一段时间。拟议的数据核心将包括Mark Nijland博士(CPNR-Core PI)、Susan Jenkins MS (CPNR-研究员)，东斌谢马(CPNR-电子工程师)，将命名为DATA 入门/分析师和顾问Mark Sharp博士(西南基金会计算服务总监 生物医学研究[SFBR])和约翰·斯库尔菲尔德(UTHSCSA生物统计学家)。 CPNR正在不断更新其数据收集和分析能力。数据采集 系统(DAS)一直是最先进的。在过去的几年里，发展努力 专注于数据共享和协作、基于互联网的数据展示和实验室等领域 信息系统。经过努力，利用互联网已成为日常工作中不可或缺的一部分。 使CPNR、SFBR以及全国和 在国际上。历史上，这些解决方案中的许多都是使用硬件和软件实现的 在本地管理。最近，一些软件解决方案已经过渡到商业Web服务，它是 建议在未来使用托管主机或专用商业互联网服务器，从而消除 需要内部维护和升级，同时最大限度地提高灵活性并将园区风险降至最低 信息技术基础设施。通过万维网访问是提供访问的关键 以高效的方式实现数据核心。上述五种方法中的每一种都在第7节中进行了详细描述 下面。

Objectives In accordance with the NIH guidelines for a PO1, the Data Core is designed as "a service or a resource component" and therefore is not designed to pose research questions. The objective of this core is to maintain, implement, and provide quality control and end user support for data acquisition, statistical analysis and data presentation. These objectives are achieved through: 1. Animal information management 2. Data acquisition hardware, software and electronics support 3. Tissue inventory and archive management 4. Centralized data analysis, presentation and data archiving 5. Internet-based sharing and distribution In addition the Data Core is equipped to provide design, fabrication, implementation and maintenance support for the acquisition subsystems used during the in vivo experiments proposed within each Project. The Center for Pregnancy and Newborn Research (CPNR) at San Antonio currently has a data acquisition, computing and statistics group that has functioned successfully as a core for many years. Dr Nijland, Ms Jenkins and Mr Xie have worked to provide similar core functionality for the PO1 being renewed through this application. In addition, members of this team have provided core services for two PO1 grants simultaneously over a 5 year period in the past. The proposed Data Core will include Mark Nijland PhD (CPNR - Core PI), Susan Jenkins MS (CPNR - Research Associate), Dongbin Xie MA (CPNR - Electronics Engineer), To Be Named data entry/analyst and consultants Mark Sharp PhD (Director of Computing Services, Southwest Foundation for Biomedical Research [SFBR]) and John Schoolfield (Biostatistician, UTHSCSA). The CPNR is continually updating its data collection and analysis capabilities. The data acquisition systems (DAS) have always been state-of-the-art. Over the past several years development efforts have been focused in such areas as data sharing and collaboration, internet-based data presentation and laboratory information systems. Utilizing the internet has become an integral part of routine operations as a result of efforts to allow smooth access to information by investigators located within the CPNR, SFBR, as well as nationally and internationally. Historically many of these solutions have been implemented using hardware and software managed locally. Recently some software solutions have been transitioned to a commercial web service, and it is proposed to use a Managed Host or dedicated commercial internet server in the future, thereby removing the need for in-house maintenance and upgrade while maximizing flexibility and minimizing risk to campus information technology infrastructure. Accessibility via the World Wide Web is the key to providing access to the Data Core in an efficient manner. Each of the five approaches listed above are described in detail in Section 7 below.