DATA ACQUISITION, ANALYSIS AND MANAGEMENT CORE

目标 根据NIH对PO 1的指导方针，数据核心被设计为“服务或资源 因此，它不是用来提出研究问题的。这个核心的目标是保持， 实施并提供数据采集、统计分析和数据处理方面的质量控制和最终用户支持 演示文稿.这些目标是通过以下方式实现的： 1.动物信息管理 2.数据采集硬件、软件和电子支持 3.组织库存和档案管理 4.集中的数据分析、列报和数据存档 5.基于互联网的共享和分发 此外，数据核心还可为以下项目提供设计、制造、实施和维护支持： 在每个项目中拟定的体内实验期间使用的采集子系统。 圣安东尼奥的妊娠和新生儿研究中心（CPNR）目前有一个数据采集， 计算和统计小组多年来一直成功地发挥核心作用。Nijland博士，Jenkins女士 和谢先生一直致力于为通过此应用程序更新的PO 1提供类似的核心功能。 此外，该团队的成员在5年内同时为两项PO 1赠款提供了核心服务 过去的一段时间。拟定的数据核心将包括Mark Nijland PhD（CPNR -核心PI）、Susan Jenkins MS (CPNR- 研究助理），谢东斌马（CPNR -电子工程师），待命名数据 入门/分析师和顾问Mark Sharp博士（西南基金会计算服务总监， Biomedical Research [SFBR]）和John Schoolfield（UTHSCSA生物统计学家）。 CPNR不断更新其数据收集和分析能力。数据采集 系统（DAS）一直是最先进的。在过去的几年里， 侧重于数据共享和协作、基于互联网的数据展示和实验室 信息系统。由于努力，利用互联网已成为日常业务的一个组成部分， 允许位于CPNR、SFBR以及全国范围内的调查人员顺利获取信息， 化国际大从历史上看，这些解决方案中的许多都是使用硬件和软件实现的 本地管理。最近，一些软件解决方案已经过渡到商业Web服务， 建议在未来使用托管主机或专用商业互联网服务器，从而消除 需要内部维护和升级，同时最大限度地提高灵活性并最大限度地降低园区风险 信息技术基础设施。通过万维网的可访问性是提供访问的关键， 以高效的方式使用数据核心。第7节详细介绍了上述五种方法中的每一种 下面

Objectives In accordance with the NIH guidelines for a PO1, the Data Core is designed as "a service or a resource component" and therefore is not designed to pose research questions. The objective of this core is to maintain, implement, and provide quality control and end user support for data acquisition, statistical analysis and data presentation. These objectives are achieved through: 1. Animal information management 2. Data acquisition hardware, software and electronics support 3. Tissue inventory and archive management 4. Centralized data analysis, presentation and data archiving 5. Internet-based sharing and distribution In addition the Data Core is equipped to provide design, fabrication, implementation and maintenance support for the acquisition subsystems used during the in vivo experiments proposed within each Project. The Center for Pregnancy and Newborn Research (CPNR) at San Antonio currently has a data acquisition, computing and statistics group that has functioned successfully as a core for many years. Dr Nijland, Ms Jenkins and Mr Xie have worked to provide similar core functionality for the PO1 being renewed through this application. In addition, members of this team have provided core services for two PO1 grants simultaneously over a 5 year period in the past. The proposed Data Core will include Mark Nijland PhD (CPNR - Core PI), Susan Jenkins MS (CPNR - Research Associate), Dongbin Xie MA (CPNR - Electronics Engineer), To Be Named data entry/analyst and consultants Mark Sharp PhD (Director of Computing Services, Southwest Foundation for Biomedical Research [SFBR]) and John Schoolfield (Biostatistician, UTHSCSA). The CPNR is continually updating its data collection and analysis capabilities. The data acquisition systems (DAS) have always been state-of-the-art. Over the past several years development efforts have been focused in such areas as data sharing and collaboration, internet-based data presentation and laboratory information systems. Utilizing the internet has become an integral part of routine operations as a result of efforts to allow smooth access to information by investigators located within the CPNR, SFBR, as well as nationally and internationally. Historically many of these solutions have been implemented using hardware and software managed locally. Recently some software solutions have been transitioned to a commercial web service, and it is proposed to use a Managed Host or dedicated commercial internet server in the future, thereby removing the need for in-house maintenance and upgrade while maximizing flexibility and minimizing risk to campus information technology infrastructure. Accessibility via the World Wide Web is the key to providing access to the Data Core in an efficient manner. Each of the five approaches listed above are described in detail in Section 7 below.