Ang II 诱发的高血压：Ac-SDKP 在终末器官损伤中的作用-猫眼课题宝

Ang II 诱发的高血压：Ac-SDKP 在终末器官损伤中的作用

批准号：

7249766

负责人：

Oscar A. Carretero

金额：

$41.32万

依托单位：

HENRY FORD HEALTH SYSTEM

依托单位国家：

美国

项目类别：

财政年份：

2007

资助国家：

美国

项目状态：

已结题

起止时间：

2007-09-01 至 2012-07-31

来源：

https://reporter.nih.gov/project-details/7249766

关键词：

AGTR2 gene Albuminuria Angiotensin II Angiotensin-Converting Enzyme Inhibitors Anti-Inflammatory Agents Anti-inflammatory Antioxidants Aorta Arteries Arts Attenuated Biostatistics Core Blood Circulation Blood Pressure Blood Vessels Bone Marrow Stem Cell Cardiac Cardiovascular system Carotid Arteries Cell Adhesion Molecules Cell Proliferation Cells Chronic Kidney Failure Collagen Complement Core Facility Development Diabetes Mellitus Dinoprostone Doctor of Medicine Doctor of Philosophy EP4 receptor Elasticity Endocrine Epithelial Cells Equilibrium Fibroblasts Fibrosis Functional disorder Galectin 3 Generations Growth Heart Diseases Heart Hypertrophy Heart failure Hormones Hydrolysis Hypertension Hypertrophy ITGAM gene Immune In Vitro Infiltration Inflammation Inflammatory Infusion procedures Kidney Kidney Diseases Kinins Macrophage Activation Mediating Mediation Microcirculation Modeling Molecular Monoclonal Antibodies Mus Mutant Strains Mice Myocardial Infarction Myofibroblast Natriuretic Factors Nephrectomy Nephrons Organ PTGS2 gene Peptidyl-Dipeptidase A Pericardial body location Peripheral Peripheral Vascular Diseases Physiological Play Pore Proteins Principal Investigator Proteinuria Rattus Regulation Renal function Research Personnel Resistance Risk Factors Role Signal Transduction Sodium Sodium Chloride Stem cells Stroke System Testing Therapeutic Effect Type 2 Angiotensin II Receptor Vasodilation Vasodilation disorder Water Wild Type Mouse Yang absorption abstracting arteriole autocrine concept connective tissue growth factor cytokine glomerulosclerosis goralatide improved in vivo inhibitor/antagonist interstitial kidney vascular structure macrophage mesangial cell migration monocyte nephrin novel oxidation paracrine pressure prevent programs protective effect receptor transcription factor

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项目成果

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中文摘要

翻译

首席研究员/项目主管（最后、第一、中）：CaiTeterO, Oscar A， M.D.

英文摘要

Principal Investigator/Program Director (Last, First, Middle): CaiTeterO, Oscar A., M.D. PROJECT I Ang ll-lnduced Hypertension: Role of Ac-SDKP in End Organ Damage Principal Investigator: Oscar A. Carretero, M.D. Co-Investigator: Nour-Eddine Rhaleb, Ph.D. Co-Investigator: Xiao-Ping Yang, M.D. Co-Investigator: Pamela Harding, Ph.D. Co-Investigator: Patrick Pagano, Ph.D. Co-Investigator: Yun-He Liu, M.D. Abstract Hypertension is a major risk factor for myocardial infarction, stroke, peripheral vascular disease, heart failure and chronic renal disease. Angiotensin II (Ang II) plays a

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