ZEBRAFISH GENETICS CORE

研究核心单元概述 斑马鱼遗传学核心对所有三个组件项目（CP）都至关重要。它将提供最先进的 资源与野生型和突变斑马鱼系，并产生胚胎进行分析， 三个CP它将允许参与的研究者维持现有的野生型和突变株系; 通过诱变，然后进行表型或基于序列的筛选，产生新的突变株系;繁殖和 筛选携带新突变的家族;通过精子冷冻保存来保存品系。它将提供设施 用于处理三种CP的所有野生型和突变体杂交以及初始表型分析。 该设施坐落在一个新装修的2800平方英尺的设施。机构主任是一名博士。的科学家 在研究和管理研究设施方面具有丰富的经验。她将由一名助理协助 经理谁是专家在斑马鱼护理，全职技术人员负责维护的 养殖系统，并由几个助手谁将处理日常畜牧业，包括饲料，坦克 清洁等

Overview of Research Core Unit The Zebrafish Genetics Core is critical to all three Component Projects (CPs). It will provide state-of-the-art resources for working with wildtype and mutant zebrafish lines, and generate the embryos to be analyzed in the three CPs. It will allow the participating investigators to maintain existing wildtype and mutant lines; generate new mutant lines by mutagenesis followed by phenotypic or sequence-based screening; propagate and screen families harboring new mutations; and preserve lines by sperm cryopreservation. It will provide facilities for handling all of the wildtype and mutant crosses for the three CPs, as well as for initial phenotypic analyses. The facility is housed in a newly-renovated 2800 sq ft facility. The Facility Director is a Ph.D. scientist with extensive experience in research and in management of research facilities. She will be assisted by an Assistant Manager who is expert in zebrafish care, a full-time technician responsible for the maintenance of the aquaculture system, and by several helpers who will handle daily animal husbandry including feeding, tank cleaning, etc.