COBRE: WVU: SIGNAL TRANSDUCTION & CANCER: ADMINISTRATIVE CORE

COBRE：西弗吉尼亚大学：信号传导

• 批准号: 7720590
• 负责人: Daniel Charles Flynn
• 金额: $ 32.37万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720590
• 关键词: Address; Affect; Appalachian Region; Basic Cancer Research; Basic Science; Bioinformatics; Cancer Center; Cancer Research Project; Cervical; Clinical Cancer Center; Clinical Research; Clinical Trials; Commit; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Depth; Development; Equipment; Faculty; Flow Cytometry; Fostering; Funding; Goals; Grant; Head and neck structure; Health Sciences; Institution; Lead; Lung; Malignant Neoplasms; Mentors; NCI-Designated Cancer Center; Ovarian; Patients; Phase; Pilot Projects; Population; Proteomics; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Signal Transduction; Source; Translational Research; Underserved Population; United States National Institutes of Health; Universities; West Virginia; cancer prevention; fight against; health disparity; malignant breast neoplasm; member; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cancer disproportionately affects the citizens of West Virginia and Appalachia, as evidenced by health disparities in cervical, lung, head & neck, ovarian and breast cancers. The Mary Babb Randolph Cancer Center (MBRCC) was established at West Virginia University to address the cancer problem in our region. Toward that goal we plan to establish a cancer center that meets the criteria for NCI designation as a Clinical Cancer Center for our underserved population. NCI designated Cancer Centers were established to lead the fight against cancer as evidenced by (a) strong basic and clinical research programs, (b) an active cancer prevention and control program and (c) an active clinical trials program. The goal of the first phase (Phase I) of our CoBRE program was to foster these institutional goals through the development of strong and interactive basic cancer research programs. In Phase I, the MBRCC coordinated cancer center membership and organization of programs, provided matching support for pilot projects, core facilities and lab/office space for new faculty hires. In addition, the West Virginia University Health Sciences Center committed tenure-track faculty lines for new faculty hires and resources for startup packages, administrative support, renovations for labs and core facilities and funds for core equipment. During Phase I, the CoBRE provided support for five junior faculty basic research projects, core facility infrastructure for new and existing faculty and matching funds for faculty recruitment. In Phase I of the CoBRE, we were successful in recruiting 8 new faculty members, mentoring 5 junior faculty members to independent research project grant (RPG) funding, establishing two new core facilities and expanding the scope of a 3rd core facility. In this renewal application (Phase II), we seek to add depth to our basic science research programs with a long term goal of integrating basic research projects with translational research programs. The Specific Aims of Phase II are to (a) maintain an Administration Core that guides and develops the CoBRE program (b) support 3 core facilities in Flow Cytometry, Proteomics and Bioinformatics that foster our research programs and (c) support five junior faculty research projects and mentor these faculty members to independence. The Administration core (Aim #1) will oversee this effort. This CoBRE program will foster our long term goal of achieving NCI designation as a Clinical Cancer Center that serves the patient population of West Virginia and the surrounding Appalachian region.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 癌症对西弗吉尼亚州和阿巴拉契亚地区居民的影响尤为严重，宫颈癌、肺癌、头颈癌、卵巢癌和乳腺癌的健康差异就证明了这一点。玛丽·巴布·伦道夫癌症中心 (MBRCC) 在西弗吉尼亚大学成立，旨在解决我们地区的癌症问题。 为了实现这一目标，我们计划建立一个符合 NCI 指定标准的癌症中心，作为服务不足人群的临床癌症中心。 NCI 指定的癌症中心的建立是为了领导抗击癌症的斗争，这一点体现在 (a) 强大的基础和临床研究计划、(b) 积极的癌症预防和控制计划以及 (c) 积极的临床试验计划。 我们 CoBRE 计划第一阶段（第一阶段）的目标是通过开发强大且互动的基础癌症研究计划来促进这些机构目标。 在第一阶段，MBRCC 协调了癌症中心的成员资格和项目组织，为试点项目、核心设施和新聘教员的实验室/办公空间提供了配套支持。 此外，西弗吉尼亚大学健康科学中心还承诺为新聘用的教员提供终身教职，并为启动包、行政支持、实验室和核心设施的翻修提供资源，并为核心设备提供资金。 在第一阶段，CoBRE 为五个初级教师基础研究项目、新教师和现有教师的核心设施基础设施以及教师招聘的配套资金提供了支持。 在 CoBRE 的第一阶段，我们成功招募了 8 名新教员，指导 5 名初级教员获得独立研究项目拨款 (RPG) 资金，建立了两个新的核心设施，并扩大了第三个核心设施的范围。 在本次更新申请（第二阶段）中，我们寻求增加基础科学研究项目的深度，长期目标是将基础研究项目与转化研究项目相结合。 第二阶段的具体目标是 (a) 维护一个指导和开发 CoBRE 计划的管理核心 (b) 支持流式细胞术、蛋白质组学和生物信息学领域的 3 个核心设施，以促进我们的研究项目；(c) 支持五个初级教员研究项目并指导这些教员独立。 管理核心（目标#1）将监督这项工作。 该 CoBRE 计划将促进我们的长期目标，即实现 NCI 指定为临床癌症中心，为西弗吉尼亚州和周边阿巴拉契亚地区的患者群体提供服务。