IMPACT OF CALCIUM INTAKE ON BODY COMPOSITION AND BLOOD LIPIDS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 超重和肥胖是波多黎各的主要公共卫生问题，影响到60%以上的人口。 最近的临床研究表明，高钙摄入可以显著降低肥胖个体的体重、脂肪量和血脂。 目前还不清楚这种影响是由于钙单独或乳制品中的其他成分，以及这些影响是否在西班牙裔人群中看到。我们建议做这项研究，以测试的假设，高钙摄入量导致身体成分和血脂的变化，在一组肥胖的波多黎各成年人。 我们进一步假设，在一组肥胖的波多黎各成年人中，乳制品钙摄入量比元素钙和元素钙摄入量对身体成分和血脂更有效。 30名受试者将被随机分配到治疗组，为期6个月：对照组或低乳组（钙700 mg/d）、高乳钙组（钙1300 mg/d）和高元素钙组（钙1300 mg/d）。 最初将根据3天的记录估计膳食营养素摄入量和体力活动。 将根据这些估计值计算研究期间受试者的等热量饮食。 受试者将被要求保持他们的体力活动水平恒定。 将在研究开始和结束时通过双能X线吸收测定法测量身体组成，并每月通过人体测量法测量身体组成。 将在研究开始和结束时测量血脂。如果增加乳制品和/或元素钙的摄入导致该组肥胖受试者的身体组成和血脂的积极变化，那么增加习惯性钙摄入将显著影响肥胖症以及其他疾病的治疗。 需要进一步的研究来证实这些结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Overweight and obesity are major public health problems in Puerto Rico, affecting more than 60% of the population. Recent clinical research has shown that a high calcium intake can significantly reduce body weight, fat mass, and blood lipids in obese indivuduals. It is unclear whether this effect is due to calcium alone or to other constituents in dairy products and if these effects are seen in the Hispanics population. We propose to do this study to test the hypothesis that a high calcium intake leads to changes in body composition and blood lipids in a group of obese Puerto Rican adults. We further hypothesize that dairy calcium intake is more effective that elemental calcium and elemental calcium intake on body composition and blood lipids in a group of obese Puerto Rican adults. Thirty subjects will be randomized into a treatment groups for 6 months: a control group or low dairy group (700mg/d of calcium), a high dairy calcium group (1300 mg/d of calcium) and a high elemental calcium group (1300 mg/d of calcium). Usual nutrient intake and physical activity will be estimated initially from 3-day records. Isocaloric diets will be calculated from these estimates for subjects to follow during the course of the study. Subjetcs will be asked to maintain their level of physical activity constant. Body composition will be measured at the beginning and the end of the study by dual-energy x-ray absorptiometry and monthly by anthropometric measurements. Blood lipids will be measured at the beginning and at the end of the study. If increasing dairy and/or elemental clacium intake leads to positive changes in body composition and blood lipids in this group of obese subjects, then increasing habitual calcium intake would significantly impact the treatment of obesity, as well as other diseases. Further studies will be needed to confirm these results.