Modulation of brain GABA receptor function by ganaxolone as a novel treatment for neurogenic hypertension

加奈索酮调节脑 GABA 受体功能作为神经源性高血压的新型治疗方法

• 批准号: nhmrc : GNT1162165
• 金额: $ 66.64万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulation-brain-gaba-neurogenic-hypertension/1379212
• 关键词: Modulation; brain; GABA; receptor; function

We identified that mice bred to have high blood pressure have an overactive nervous system due to a faulty molecule in a distinct region of the brain. The high nervous activity affects the kidney and leads to high blood pressure. The proposal will determine the effects of a novel treatment to reverse the changes in the brain and thereby normalize blood pressure. This will lead to new therapy opportunities and reduce the major risk factor of cardiovascular disease.

我们发现，由于大脑不同区域的分子缺陷，高血压小鼠的神经系统过度活跃。高神经活动影响肾脏，导致高血压。该提案将确定一种新疗法的效果，以逆转大脑的变化，从而使血压正常化。这将带来新的治疗机会，并减少心血管疾病的主要危险因素。