CORE: SIGNAL TRANSDUCTION CORE FACILITY

核心：信号传导核心设施

• 批准号: 7720051
• 负责人: Kenneth Mark Coggeshall
• 金额: $ 7.06万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720051
• 关键词: Apoptosis; Biochemistry; Biological; Biological Assay; Cell Differentiation process; Cells; Cellular biology; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Development; Equipment; Event; Exhibits; Funding; Grant; Homeostasis; Housing; Immune; Immune response; Immune system; Institution; Knowledge; Laboratories; Ligands; Protein Tyrosine Kinase; Regulation; Research; Research Personnel; Resources; Role; Signal Transduction; Signal Transduction Induction; Source; System; Techniques; United States National Institutes of Health; cytokine; driving force; experience; genetic regulatory protein; knowledge base; protein protein interaction; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Receptor-ligand interactions and the induction of signal transduction biochemistry are the driving force for all regulatory events in cell biology. This regulation is especially evident in the immune system, which exhibits numerous receptor-ligand interactions that promote immune cell differentiation, proliferation, apoptosis, and activation of effector functions. Accordingly, signal transduction biochemistry is central to understanding the biological events within immune cell homeostasis. The body of knowledge of immune cell signaling has matured considerably over the past ten years, especially with the discovery of the central role for tyrosine protein kinases in regulatory protein-protein interactions. Since it is a nascent field, the techniques used to study signaling events induced by cytokines or other immune cell activators are fairly specialized and perhaps not readily acquired by inexperienced laboratories without direct support. Given the similarity of assays that apply from one receptor to another, we expect benefit from past experience for those who study related signaling systems. Thus, this application proposes to continue to support a core facility to house expertise and equipment that focuses on immune cell signal transduction biochemistry. It will be used as a knowledge-base and technical resource for new investigators who find a need to explore signaling events in various immune responses, and will facilitate development and transfer of expertise and specific assays to researchers studying other signaling networks.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 受体配体相互作用和信号转导生物化学的诱导是细胞生物学中所有调节事件的驱动力。 这种调节在免疫系统中尤其明显，该免疫系统表现出众多促进免疫细胞分化，增殖，凋亡和效应子功能激活的相互作用。 因此，信号转导生物化学对于了解免疫细胞体内稳态内的生物学事件至关重要。 在过去的十年中，免疫细胞信号传导的知识已经大大成熟，尤其是发现酪氨酸蛋白激酶在调节性蛋白质蛋白质相互作用中的核心作用。 由于它是一个新生的领域，因此用于研究细胞因子或其他免疫细胞激活剂引起的信号传导事件的技术相当专业，也许没有直接支持的经验实验室不容易获得。 鉴于从一个受体到另一个受体的测定法的相似性，我们希望过去的经验受益于研究相关信号系统的人。 因此，本申请建议继续支持核心设施，以介绍关注免疫细胞信号转导生物化学的专业知识和设备。 它将用作新研究人员的知识库和技术资源，他们发现需要探索各种免疫反应中的信号事件，并将促进对研究其他信号网络的研究人员的发展和转移。