HIV-1 SUBTYPE C FITNESS EVOLUTION AND MOTHER TO CHILD TRANSMISSION

HIV-1 C 亚型健康进化和母婴传播

• 批准号: 7725291
• 负责人: JOHN WEST
• 金额: $ 6.93万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725291
• 关键词: Amino Acids; Computer Retrieval of Information on Scientific Projects Database; Evaluation; Evolution; Funding; Genetic Polymorphism; Grant; HIV Envelope Protein gp120; Institution; Outcome; Physiologic pulse; Process; Pulse taking; Research; Research Personnel; Resources; Source; System; United States National Institutes of Health; Vertical Disease Transmission; Virus; fitness

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The significance of our current findings is that they demonstrate that the fluorescent viruses are infectious and thus will be excellent platforms for carrying out the fitness evaluations proposed. Moreover the finding that in our pulse chase analyses that there are significant alterations in processing and in gp120 shedding is almost certain to have impact on the outcome of other phenotypic evaluations such as incorporation and fusion. These parameters, in turn will impact fitness. Therefore it seems likely that the system will detect fitness differences and those differences will be attributable to amino acid polymorphisms between different C2-V4 regions.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们目前的研究结果的意义在于，它们证明了荧光病毒是传染性的，因此将是进行所提出的适应性评估的极好平台。此外，在我们的脉冲追踪分析中发现，在处理和gp 120中存在显著的改变， 脱落几乎肯定会影响其它表型评价如掺入和融合的结果。这些参数反过来又会影响健身。因此，该系统很可能会检测到适应性差异，而这些差异将归因于氨基酸多态性 在不同的C2-V4区域之间。