NEW AVIAN LUNG, RIGIDITY OF CAPILLARIES, EPITHELIAL BRIDGES, AIR CAPILLARIES

新禽肺、毛细血管刚性、上皮桥、空气毛细血管

• 批准号: 7957653
• 负责人: JOHN WEST
• 金额: $ 4.83万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-15 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957653
• 关键词: Air; Birds; Blood capillaries; Computer Retrieval of Information on Scientific Projects Database; Electron Microscope; Epithelial; Funding; Grant; Image Analysis; Institution; Lung; Mammals; Muscle Rigidity; Oxygen; Physiology; Pulmonary Circulation; Research; Research Personnel; Resources; Source; Tissues; United States National Institutes of Health; Vertebrates; capillary; tomography; voltage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The two great classes of vertebrates capable of sustained high oxygen consumptions, the birds and mammals, share many similarities of physiology but have radically different lungs. There is evidence that the avian pulmonary circulation is very different from that in mammals in that the avian pulmonary capillaries appeared to be essentially rigid. The reason for this are not understood but probably have to do ultrastructure of the tissues surrounding the capillaries, and the facilities of the NCMIR with its high voltage electron microscope tomography are well suited to elucidating this problem.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 能够持续高耗氧的两大类脊椎动物——鸟类和哺乳动物——在生理学上有许多相似之处，但肺部却截然不同。有证据表明鸟类的肺循环与哺乳动物的肺循环有很大不同，因为鸟类的肺毛细血管似乎基本上是刚性的。其原因尚不清楚，但可能与毛细血管周围组织的超微结构有关，NCMIR 的高压电子显微镜断层扫描设备非常适合阐明这个问题。