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AZTREONAM LYSINATE IN CF PATIENTS WITH PULMONARY PNEUMONIA AERUGINOSA

AZTREONAM LYSINATE IN CF PATIENTS WITH PULMONARY PNEUMONIA AERUGINOSA
赖氨酸氨曲南治疗铜绿型肺肺炎 CF 患者
批准号:
7604924
负责人:
RICHARD C AHRENS
金额:
$0.07万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-03-01 至 2007-09-16

项目摘要

项目成果

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中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a phase 3 study to assess the safety and efficacy of a 28-day treatment with Aztreonam Lysinate for inhalation (AI) in people with cystic fibrosis and positive Pa sputum/throat cultures aged greater than or equal to 6 with FEV1 between 25 and 75% predicted. It is a double-blind, randomized, placebo-controlled, multi-national, multi-center study. Subjects will receive 28 days of treatment with either 75 mg AI or placebo, taken 3 times a day using the eFlow nebulizer. The study consists of 5 outpatient visits - screening, treatment day 1, 14, 28 and 2-week follow-up visit. Only a few antibiotics are approved for inhaled therapy for Pa in CF. Aztreonam is approved for IV administration and is active against Pa. AI is a different salt form from the IV formulation to lessen the pulmonary irritation/bronchoreactivity.
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STANDARD VERSUS BIOFILM SUSCEPTIBILITY TESTING IN CYSTIC FIBROSIS
  • 批准号:
    7604823
  • 项目类别:
  • 资助金额:
    $0.08万
  • 财政年份:
    2007
  • 负责人:
    RICHARD C AHRENS
  • 依托单位:
GENETIC MODIFIERS OF CYSTIC FIBROSIS: SIBLING STUDY
  • 批准号:
    7604893
  • 项目类别:
  • 资助金额:
    $0.14万
  • 财政年份:
    2007
  • 负责人:
    RICHARD C AHRENS
  • 依托单位:
EURAND PANCREATIC ENZYME PRODUCT MICROTABS IN PEDIATRIC CF PATIENTS
  • 批准号:
    7604898
  • 项目类别:
  • 资助金额:
    $0.19万
  • 财政年份:
    2007
  • 负责人:
    RICHARD C AHRENS
  • 依托单位:
ULTRASE MT20 FOR CORRECTION OF STEATORRHEA IN PATIENTS WITH CYSTIC FIBROSIS
  • 批准号:
    7604922
  • 项目类别:
  • 资助金额:
    $2.21万
  • 财政年份:
    2007
  • 负责人:
    RICHARD C AHRENS
  • 依托单位:
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