BODY COMPOSITION AND FUNCTIONAL ANALYSIS OF KNEE OSTEOARTHRITIS TO OBESITY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 膝关节骨关节炎（OA）是残疾的常见原因，肥胖是一个很强的风险因素。 肥胖与髋关节OA之间没有相关性，女性BMI与膝关节OA之间的相关性比男性更强，这表明体重增加本身可能无法解释膝关节OA风险升高。 肥胖和膝关节OA之间关系的机制尚未确定，但已提出相对股四头肌无力和内侧间室负荷增加。 先前的研究已经表明，肥胖受试者比非肥胖受试者具有更大的绝对股四头肌力量。 本研究将检查正常体重和患有和不患有膝关节OA的肥胖受试者之间的力量：下肢瘦体重（LBM）关系是否存在差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteoarthritis (OA) of the knee is a common cause of disability, and obesity is a strong risk factor. There has been no association between obesity and hip OA and the correlation between BMI and knee OA has been stronger in women than men, suggesting that increased weight alone may not account for elevated knee OA risk. The mechanism for the relationship between obesity and knee OA has not been established, but both relative quadriceps weakness and increased medial compartment loading have been proposed. Prior studies have shown that obese subjects have greater absolute quadriceps strength than non-obese subjects. This study will examine whether there are differences in the strength:lower limb lean body mass (LBM) relationship between normal weight and obese subjects with and without knee OA.