BODY COMPOSITION AND FUNCTIONAL ANALYSIS OF KNEE OSTEOARTHRITIS TO OBESITY

这个子项目是众多研究子项目之一

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteoarthritis (OA) of the knee is a common cause of disability, and obesity is a strong risk factor. There has been no association between obesity and hip OA and the correlation between BMI and knee OA has been stronger in women than men, suggesting that increased weight alone may not account for elevated knee OA risk. The mechanism for the relationship between obesity and knee OA has not been established, but both relative quadriceps weakness and increased medial compartment loading have been proposed. Prior studies have shown that obese subjects have greater absolute quadriceps strength than non-obese subjects. This study will examine whether there are differences in the strength:lower limb lean body mass (LBM) relationship between normal weight and obese subjects with and without knee OA.