BODY COMPOSITION AND FUNCTIONAL ANALYSIS OF KNEE OSTEOARTHRITIS TO OBESITY

膝骨关节炎至肥胖的身体成分和功能分析

• 批准号: 7604845
• 负责人: NEIL SEGAL
• 金额: $ 0.58万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604845
• 关键词: Accounting; Body Composition; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Hip Osteoarthritis; Institution; Knee Osteoarthritis; Lower Extremity; Medial; Non obese; Obesity; Relative (related person); Research; Research Personnel; Resources; Risk; Risk Factors; Source; United States National Institutes of Health; Weight; Weight Gain; Woman; disability; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteoarthritis (OA) of the knee is a common cause of disability, and obesity is a strong risk factor. There has been no association between obesity and hip OA and the correlation between BMI and knee OA has been stronger in women than men, suggesting that increased weight alone may not account for elevated knee OA risk. The mechanism for the relationship between obesity and knee OA has not been established, but both relative quadriceps weakness and increased medial compartment loading have been proposed. Prior studies have shown that obese subjects have greater absolute quadriceps strength than non-obese subjects. This study will examine whether there are differences in the strength:lower limb lean body mass (LBM) relationship between normal weight and obese subjects with and without knee OA.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 膝骨关节炎 (OA) 是导致残疾的常见原因，而肥胖是一个很强的危险因素。 肥胖与髋部 OA 之间没有关联，并且女性 BMI 与膝部 OA 之间的相关性比男性更强，这表明体重增加可能并不能解释膝部 OA 风险升高。 肥胖与膝关节骨关节炎之间关系的机制尚未确定，但已提出股四头肌相对无力和内侧筋膜室负荷增加。 先前的研究表明，肥胖受试者比非肥胖受试者具有更大的绝对股四头肌力量。 本研究将检验正常体重和患有或不患有膝骨关节炎的肥胖受试者之间的力量：下肢去脂体重 (LBM) 关系是否存在差异。