CARDIOVASCULAR RISK FACTORS IN WOMEN WITH PCOS

多囊卵巢综合征女性的心血管危险因素

• 批准号: 7604877
• 负责人: ANUJA DOKRAS
• 金额: $ 1万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604877
• 关键词: Affect; Atherosclerosis; Calcium; Complex; Computer Retrieval of Information on Scientific Projects Database; Coronary artery; Funding; Grant; Hypertension; Inflammatory; Institution; Insulin; Insulin Resistance; Metabolic syndrome; Metformin; Obesity; Ovarian; Ovulation Induction; Pharmaceutical Preparations; Population; Premenopause; Research; Research Personnel; Resources; Risk; Score; Source; Syndrome; United States National Institutes of Health; Weight; Woman; cardiovascular risk factor; impaired glucose tolerance; lipid disorder

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic ovarian syndrome (PCOS) is a complex syndrome affecting 5-10% of premenopausal women, with known associated risks of lipid disorders, insulin resistance, impaired glucose tolerance and hypertension. These investigators hypothesize that obese women with PCOS will have increased levels of inflammatory markers and evidence of atherosclerosis (as determined by higher coronary artery calcium scores) than weight-matched controls without PCOS. They will correlate these factors with the presence of the metabolic syndrome within this population. They also hypothesize that metformin, a drug commonly used in women with PCOS for its insulin sensitization and ovulation induction effects, will reduce levels of inflammatory markers in the obese PCOS women.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 多囊卵巢综合征（PCOS）是一种复杂的综合征，影响5-10%的绝经前妇女，已知与血脂紊乱、胰岛素抵抗、葡萄糖耐量受损和高血压相关的风险。 这些研究者假设，与体重匹配的对照组相比，患有PCOS的肥胖女性的炎症标志物水平和动脉粥样硬化的证据（由较高的冠状动脉钙评分确定）增加。 他们将这些因素与该人群中代谢综合征的存在相关。 他们还假设二甲双胍，一种常用于PCOS女性的胰岛素增敏和促排卵作用的药物，将降低肥胖PCOS女性的炎症标志物水平。