EFFECTS OF PHENYTOIN ON DRIVING SAFETY
苯妥英对驾驶安全的影响
基本信息
- 批准号:7604917
- 负责人:
- 金额:$ 0.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-03-01 至 2007-09-16
- 项目状态:已结题
- 来源:
- 关键词:AmericanAntiepileptic AgentsArtsAttentionAutomobile DrivingCognitiveComputer Retrieval of Information on Scientific Projects DatabaseConditionCross-Over StudiesDevelopmentDouble-Blind MethodEnvironmentEpilepsyFinancial costFundingGoalsGrantGuidelinesImpaired cognitionInstitutionInterventionLifeMeasuresMedicalMemoryNeuropsychological TestsPatientsPerceptionPerformancePhenytoinPlacebo ControlPlacebosPublic HealthRandomizedResearchResearch PersonnelResourcesResponse to stimulus physiologyRiskRoleSafetySeizuresSocietiesSourceUnited States National Institutes of HealthVehicle crashbasecognitive functionexecutive functionpreventresearch studyvolunteer
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Automobile driving is a crucial aspect of everyday life, yet vehicular crashes represent a serious public health problem. Patients with epilepsy are at elevated risk for automobile crashes, causing great personal suffering and financial costs to society. Most collisions involving epileptic drivers are not seizure related but may instead result from cognitive effects upon driving performance of epilepsy and antiepileptic drugs (AEDs). Several million American drivers take AEDs for treatment of medical conditions besides epilepsy and may also be at risk for cognitive impairments that can reduce driving performance. Empirical evidence of the effects of AEDs on driving performance would enable development of driving guidelines that could lower the risk of injurious motor vehicle collisions; however, this evidence is currently lacking. The broad goal of our project is to determine the specific effects of the most commonly utilized AED, phenytoin, by assessing driving performance and cognitive abilities in neurologically normal volunteers taking phenytoin in a randomized, double-blind, placebo-controlled, crossover study. Our proposed experiments will assess: (1) cognitive functions using standardized neuropsychological tests (of attention, perception, memory, and executive functions), (2) driving performance during phenytoin and placebo administration, and (3) the effects of phenytoin-related cognitive performance upon driving performance. To measure driving performance, we will use a state-of-the-art fixed-base interactive driving simulator that allows us to observe driver errors in an environment that is challenging yet safe for the driver and tester, under conditions of optimal stimulus and response control. The results of this study of 30 drivers treated with phenytoin and placebo will increase the understanding of the role of AED-related cognitive impairment on driving safety errors. A better understanding of the impact of AEDs upon driving performance is necessary to rationally develop interventions that could help prevent crashes by drivers treated with AEDs.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
汽车驾驶是日常生活的一个重要方面,但车辆碰撞是一个严重的公共卫生问题。 癫痫患者发生车祸的风险很高,给个人造成巨大痛苦,并给社会带来经济损失。 大多数涉及癫痫驾驶员的碰撞与癫痫发作无关,但可能是由于癫痫和抗癫痫药物(AED)对驾驶性能的认知影响。 数百万美国司机服用AED治疗癫痫以外的疾病,也可能有认知障碍的风险,这可能会降低驾驶性能。 AED对驾驶性能的影响的经验证据将使驾驶指南的发展,可以降低伤害性机动车碰撞的风险,但是,目前缺乏这种证据。 我们项目的广泛目标是通过在一项随机、双盲、安慰剂对照、交叉研究中评估服用苯妥英的神经系统正常志愿者的驾驶性能和认知能力,确定最常用的AED苯妥英的具体影响。 我们拟定的实验将评估:(1)使用标准化神经心理学测试(注意力、感知、记忆和执行功能)的认知功能,(2)苯妥英和安慰剂给药期间的驾驶性能,以及(3)苯妥英相关认知性能对驾驶性能的影响。 为了测量驾驶性能,我们将使用最先进的固定底座交互式驾驶模拟器,使我们能够在最佳刺激和反应控制条件下,在具有挑战性但对驾驶员和测试员安全的环境中观察驾驶员错误。 这项研究的结果与苯妥英和安慰剂治疗的30名司机将增加AED相关的认知障碍的作用,驾驶安全错误的理解。 更好地了解AEDs对驾驶性能的影响是必要的,以合理地制定干预措施,可以帮助防止与AEDs治疗的司机撞车。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Erik Kent St. Louis其他文献
Erik Kent St. Louis的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Erik Kent St. Louis', 18)}}的其他基金
相似海外基金
Synthesis and Biological Evaluation of Disubstituted Beta-Alanines as Antiepileptic Agents
双取代β-丙氨酸抗癫痫药的合成及生物学评价
- 批准号:
480799-2015 - 财政年份:2015
- 资助金额:
$ 0.19万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Master's