OXIDATIVE STRESS MARKERS AND HIV-ASSOCIATED NEUROLOGICAL DISORDERS

氧化应激标志物和 HIV 相关神经系统疾病

• 批准号: 7604632
• 负责人: NED C SACKTOR
• 金额: $ 4.27万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604632
• 关键词: 4 hydroxynonenal; AIDS Dementia Complex; Acids; Astrocytes; Cell Death; Ceramides; Computer Retrieval of Information on Scientific Projects Database; Data; Dementia; Development; Disruption; Equilibrium; Functional disorder; Funding; Grant; HIV; Immune; Impairment; Individual; Inflammation; Institution; Laboratory Markers; Membrane Lipids; Neuraxis; Neurocognitive; Neuronal Injury; Oxidation-Reduction; Oxidative Stress; Play; Proteins; Reactive Oxygen Species; Research; Research Personnel; Resources; Role; Source; Sphingomyelins; United States; United States National Institutes of Health; cohort; cytokine; macrophage; nervous system disorder; neuroimaging; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV dementia (HIV-D) is one of the most common causes of dementia in young adults in the United States. Aberrant immune activation and oxidative stress within the central nervous system (CNS) play a significant role in the development of HIV-D. Disruptions in cytokine and redox balance produce reactive oxygen species which can attack proteins, deoxynucleic acids, and lipid membranes resulting in cellular dysfunction and cell death. Recent data from our group demonstrate increases in several markers of oxidative stress, specifically, ceramide, sphingomyelin, and 4-hydroxynonenal (HNE). The project will assemble a cohort of HIV+ individuals with varying degrees of neurocognitive impairment: 1) to define the association between markers of oxidative stress and HIV-D in a cohort of HAART-treated subjects and to determine the relationship between these markers and laboratory markers of macrophage and astrocyte activation and neuroimaging markers of inflammation and neuronal injury, and 2) to determine whether markers of oxidative stress predict either the reversibility or the progression of HIV-D.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 HIV痴呆（HIV-D）是美国年轻人痴呆症的最常见原因之一。中枢神经系统（CNS）内的异常免疫激活和氧化应激在HIV-D的发展中起着重要作用。细胞因子和氧化还原平衡的破坏产生活性氧物质，其可以攻击蛋白质、脱氧核酸和脂质膜，导致细胞功能障碍和细胞死亡。我们小组最近的数据表明，氧化应激的几个标志物增加，特别是神经酰胺，鞘磷脂和4-羟基壬烯醛（HNE）。 该项目将收集一组具有不同程度神经认知障碍的HIV+个体：1）确定HAART治疗的受试者队列中氧化应激标志物与HIV-D之间的关联，并确定这些标志物与巨噬细胞和星形胶质细胞活化的实验室标志物以及炎症和神经元损伤的神经成像标志物之间的关系，和2）确定氧化应激标志物是否预测HIV-D的可逆性或进展。