SILENT STROKE IN A POPULATION OF PATIENTS AT RISK FOR CEREBROVASCULAR DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项先导性研究的主要具体目的是证明无症状性中风在高危人群中的流行率，这些高危人群来自已知的早发冠状动脉疾病风险增加的家庭。第二个目标是确定无症状性中风与其他血管床上的隐匿性疾病的关系，主要是冠状动脉疾病。第三个目的是确定无症状性中风与炎症生物标志物、血小板功能测试和其他促凝血因子、脂类和脂蛋白、当前吸烟和最近一次来访的其他危险因素之间的关系。 最终，拨款申请的长期目标将是确定基因和基因-环境相互作用对不同形式的血管疾病的贡献，这些疾病似乎聚集在有早产儿事件的家庭中，并且似乎是由炎症介导的。在这一人群中展示MRI检测静默中风的能力是合乎逻辑的第一步。如果不确定这种存在的程度，对共享标记的遗传分析或检查将是不可能的或显著的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary specific aim of this pilot study is to demonstrate the prevalence of silent stroke within a high risk population identified from families known to be an increased risk of premature coronary disease. A secondary aim is to determine the relationship of silent stroke to occult disease in other vascular beds, primarily coronary disease. The third aim is to determine the relationship of silent stroke to inflammatory biomarkers, platelet function tests and other procoagulation factors, lipids and lipoproteins, current smoking and other risk factors characterized in this population at their most recent visit. Ultimately, the longer-term aims for grant submissions will be to determine the contribution of genes and gene-environment interactions to different forms of vascular disease that appear to cluster in families with premature events and that appear to be mediated by inflammation. Demonstrating the ability to detect silent strokes on MRI in this population is the logical first step. Without determining the extent to which this exists, genetic analysis or examination of shared markers will not be possible or salient.