ASSESSMENT OF INDUCED SPUTUM
诱发痰的评估
基本信息
- 批准号:7604596
- 负责人:
- 金额:$ 0.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-12-01 至 2007-09-16
- 项目状态:已结题
- 来源:
- 关键词:AddressAnti-Inflammatory AgentsAnti-inflammatoryClinicalClinical TrialsComputer Retrieval of Information on Scientific Projects DatabaseControl GroupsElastasesFundingGrantIbuprofenInstitutionMeasuresOutcome MeasurePancreatic ElastasePropertyRecoveryResearchResearch PersonnelResourcesSalineScreening procedureSourceSpecimenSputumTestingUnited States National Institutes of HealthUpper armWeekcelecoxibcystic fibrosis patientscytokineneutrophiltreatment duration
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
To determine whether neutrophils, active elastase, and cytokines measured in sputum induced using hypertonic saline are useful screening tests for determining if a particular agent with known anti-inflammatory properties is a suitable candidate for more extensive clinical trials in patients with CF. This aim will be addressed using one anti-inflammatory agent, ibuprofen, that has been shown to have clinical benefit in CF, and one anti-inflammatory agent, celecoxib, that has potential to have clinical benefit in CF. A "no treatment" arm will be included as the control group. The outcome measures will be assessed in induced sputum specimens before (Baseline Period), during (Treatment Period), and after (recovery Period) a 4-week treatment period in clinically stable CF patients. Changes will be assessed within each arm and between arms.
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
为了确定用高渗盐水诱导的痰中中性粒细胞、活性弹力酶和细胞因子是否是有用的筛查试验,以确定具有已知抗炎特性的特定药物是否适合进行更广泛的临床试验。这一目标将通过一种抗炎药布洛芬和一种抗炎药塞来昔布来实现,布洛芬已被证明对CF具有临床益处,塞来昔布可能对CF具有临床益处。另设“不接受治疗”的手臂作为对照组。对于临床稳定的CF患者,将在治疗前(基准期)、治疗期(治疗期)和恢复期(恢复期)之前(基准期)和之后(恢复期)对诱导痰标本的结果进行评估。变化将在每个手臂内和手臂之间进行评估。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Pamela L. Zeitlin其他文献
Net benefit of ivacaftor during prolonged tezacaftor/elexacaftor exposure emin vitro/em
- DOI:
10.1016/j.jcf.2022.02.011 - 发表时间:
2022-07-01 - 期刊:
- 影响因子:6.000
- 作者:
Ciaran A. Shaughnessy;Pamela L. Zeitlin;Preston E. Bratcher - 通讯作者:
Preston E. Bratcher
The Changing Face of Cystic Fibrosis: An Update for Anesthesiologists.
囊性纤维化的变化:麻醉师的更新。
- DOI:
10.1213/ane.0000000000005856 - 发表时间:
2022 - 期刊:
- 影响因子:5.7
- 作者:
Amy J. Lee;J. Huffmyer;Eryn L Thiele;Pamela L. Zeitlin;D. Chatterjee - 通讯作者:
D. Chatterjee
717. VCP Short Hairpin RNA Rescues ΔF508- CFTR and Suppresses IL8 Levels: Therapeutic Implications in Cystic Fibrosis
- DOI:
10.1016/j.ymthe.2006.08.796 - 发表时间:
2006-01-01 - 期刊:
- 影响因子:
- 作者:
Neeraj Vij;Shengyun Fang;Pamela L. Zeitlin - 通讯作者:
Pamela L. Zeitlin
Pamela L. Zeitlin的其他文献
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{{ truncateString('Pamela L. Zeitlin', 18)}}的其他基金
Mechanism of Prostone Activation During CFTR Modulation
CFTR 调节过程中前列酮激活的机制
- 批准号:
10687435 - 财政年份:2022
- 资助金额:
$ 0.05万 - 项目类别:
Ph 1-2 Study of Glycerolphenylbutyrate for Cystic Fibrosis IND 125,124 (12/5/15)
Ph 1-2 甘油苯基丁酸酯治疗囊性纤维化的研究 IND 125,124 (12/5/15)
- 批准号:
9322858 - 财政年份:2016
- 资助金额:
$ 0.05万 - 项目类别:
Phase 2 study of digitoxin for cystic fibrosis - IND 70279
洋地黄毒苷治疗囊性纤维化的 2 期研究 - IND 70279
- 批准号:
7566224 - 财政年份:2008
- 资助金额:
$ 0.05万 - 项目类别:
Phase 2 study of digitoxin for cystic fibrosis - IND 70279
洋地黄毒苷治疗囊性纤维化的 2 期研究 - IND 70279
- 批准号:
7689355 - 财政年份:2008
- 资助金额:
$ 0.05万 - 项目类别:
Phase 2 study of digitoxin for cystic fibrosis - IND 70279
洋地黄毒苷治疗囊性纤维化的 2 期研究 - IND 70279
- 批准号:
8238123 - 财政年份:2008
- 资助金额:
$ 0.05万 - 项目类别:
Phase 2 Study of Digitoxin for the Treatment of Cystic Fibrosis
洋地黄毒素治疗囊性纤维化的 2 期研究
- 批准号:
8747904 - 财政年份:2007
- 资助金额:
$ 0.05万 - 项目类别:
CAMP STIMULATED SWEAT RATE IN CYSTIC FIBROSIS
囊性纤维化中 CAMP 刺激出汗率
- 批准号:
7604524 - 财政年份:2006
- 资助金额:
$ 0.05万 - 项目类别:
TRANSEPITHELIAL POTENTIAL DIFFERENCE IN PTS W/ VARIANTS OF CYSTIC FIBROSIS (CF)
囊性纤维化 (CF) 变体 PTS 的跨上皮电位差
- 批准号:
7604525 - 财政年份:2006
- 资助金额:
$ 0.05万 - 项目类别:
A PHASE 2 STUDY OF PTC124 FOR CYSTIC FIBROSIS
PTC124 治疗囊性纤维化的 2 期研究
- 批准号:
7604667 - 财政年份:2006
- 资助金额:
$ 0.05万 - 项目类别:
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