ASSESSMENT OF INDUCED SPUTUM
诱发痰的评估
基本信息
- 批准号:7604596
- 负责人:
- 金额:$ 0.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-12-01 至 2007-09-16
- 项目状态:已结题
- 来源:
- 关键词:AddressAnti-Inflammatory AgentsAnti-inflammatoryClinicalClinical TrialsComputer Retrieval of Information on Scientific Projects DatabaseControl GroupsElastasesFundingGrantIbuprofenInstitutionMeasuresOutcome MeasurePancreatic ElastasePropertyRecoveryResearchResearch PersonnelResourcesSalineScreening procedureSourceSpecimenSputumTestingUnited States National Institutes of HealthUpper armWeekcelecoxibcystic fibrosis patientscytokineneutrophiltreatment duration
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
To determine whether neutrophils, active elastase, and cytokines measured in sputum induced using hypertonic saline are useful screening tests for determining if a particular agent with known anti-inflammatory properties is a suitable candidate for more extensive clinical trials in patients with CF. This aim will be addressed using one anti-inflammatory agent, ibuprofen, that has been shown to have clinical benefit in CF, and one anti-inflammatory agent, celecoxib, that has potential to have clinical benefit in CF. A "no treatment" arm will be included as the control group. The outcome measures will be assessed in induced sputum specimens before (Baseline Period), during (Treatment Period), and after (recovery Period) a 4-week treatment period in clinically stable CF patients. Changes will be assessed within each arm and between arms.
该子项目是利用该技术的众多研究子项目之一
资源由 NIH/NCRR 资助的中心拨款提供。子项目和
研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金,
因此可以在其他 CRISP 条目中表示。列出的机构是
对于中心来说,它不一定是研究者的机构。
确定使用高渗盐水诱导的痰液中测量的中性粒细胞、活性弹性蛋白酶和细胞因子是否是有用的筛选试验,以确定具有已知抗炎特性的特定药物是否适合在 CF 患者中进行更广泛的临床试验。这一目标将通过使用一种抗炎药布洛芬和一种抗炎药塞来昔布来实现,布洛芬已被证明对 CF 具有临床益处,而塞来昔布可能对 CF 具有临床益处。 “未治疗”组将被纳入作为对照组。将在临床稳定的 CF 患者的 4 周治疗期之前(基线期)、期间(治疗期)和之后(恢复期)对诱导痰标本进行结果测量评估。将评估每个臂内和臂间的变化。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Pamela L. Zeitlin其他文献
Net benefit of ivacaftor during prolonged tezacaftor/elexacaftor exposure emin vitro/em
- DOI:
10.1016/j.jcf.2022.02.011 - 发表时间:
2022-07-01 - 期刊:
- 影响因子:6.000
- 作者:
Ciaran A. Shaughnessy;Pamela L. Zeitlin;Preston E. Bratcher - 通讯作者:
Preston E. Bratcher
The Changing Face of Cystic Fibrosis: An Update for Anesthesiologists.
囊性纤维化的变化:麻醉师的更新。
- DOI:
10.1213/ane.0000000000005856 - 发表时间:
2022 - 期刊:
- 影响因子:5.7
- 作者:
Amy J. Lee;J. Huffmyer;Eryn L Thiele;Pamela L. Zeitlin;D. Chatterjee - 通讯作者:
D. Chatterjee
717. VCP Short Hairpin RNA Rescues ΔF508- CFTR and Suppresses IL8 Levels: Therapeutic Implications in Cystic Fibrosis
- DOI:
10.1016/j.ymthe.2006.08.796 - 发表时间:
2006-01-01 - 期刊:
- 影响因子:
- 作者:
Neeraj Vij;Shengyun Fang;Pamela L. Zeitlin - 通讯作者:
Pamela L. Zeitlin
Pamela L. Zeitlin的其他文献
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{{ truncateString('Pamela L. Zeitlin', 18)}}的其他基金
Mechanism of Prostone Activation During CFTR Modulation
CFTR 调节过程中前列酮激活的机制
- 批准号:
10687435 - 财政年份:2022
- 资助金额:
$ 0.05万 - 项目类别:
Ph 1-2 Study of Glycerolphenylbutyrate for Cystic Fibrosis IND 125,124 (12/5/15)
Ph 1-2 甘油苯基丁酸酯治疗囊性纤维化的研究 IND 125,124 (12/5/15)
- 批准号:
9322858 - 财政年份:2016
- 资助金额:
$ 0.05万 - 项目类别:
Phase 2 study of digitoxin for cystic fibrosis - IND 70279
洋地黄毒苷治疗囊性纤维化的 2 期研究 - IND 70279
- 批准号:
7566224 - 财政年份:2008
- 资助金额:
$ 0.05万 - 项目类别:
Phase 2 study of digitoxin for cystic fibrosis - IND 70279
洋地黄毒苷治疗囊性纤维化的 2 期研究 - IND 70279
- 批准号:
7689355 - 财政年份:2008
- 资助金额:
$ 0.05万 - 项目类别:
Phase 2 study of digitoxin for cystic fibrosis - IND 70279
洋地黄毒苷治疗囊性纤维化的 2 期研究 - IND 70279
- 批准号:
8238123 - 财政年份:2008
- 资助金额:
$ 0.05万 - 项目类别:
Phase 2 Study of Digitoxin for the Treatment of Cystic Fibrosis
洋地黄毒素治疗囊性纤维化的 2 期研究
- 批准号:
8747904 - 财政年份:2007
- 资助金额:
$ 0.05万 - 项目类别:
CAMP STIMULATED SWEAT RATE IN CYSTIC FIBROSIS
囊性纤维化中 CAMP 刺激出汗率
- 批准号:
7604524 - 财政年份:2006
- 资助金额:
$ 0.05万 - 项目类别:
TRANSEPITHELIAL POTENTIAL DIFFERENCE IN PTS W/ VARIANTS OF CYSTIC FIBROSIS (CF)
囊性纤维化 (CF) 变体 PTS 的跨上皮电位差
- 批准号:
7604525 - 财政年份:2006
- 资助金额:
$ 0.05万 - 项目类别:
A PHASE 2 STUDY OF PTC124 FOR CYSTIC FIBROSIS
PTC124 治疗囊性纤维化的 2 期研究
- 批准号:
7604667 - 财政年份:2006
- 资助金额:
$ 0.05万 - 项目类别:
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