Training in Trauma, Inflammation, Sepsis and Critical Care

描述（由申请人提供）：我们在创伤，脓毒症，炎症和重症监护培训计划的竞争性更新的具体目标是培养在生理学，分子生物学和分子遗传学方面有良好基础的医生/科学家。该计划旨在教导感兴趣的个人制定基于假设的研究计划，使学员能够将发展和新信息从长凳转移到床边，从而在创伤和重症监护中开发新颖和创新的治疗策略。该培训计划致力于两年的研究培训，培训计划的候选人必须具有认可的医学或研究生院的MD或博士学位;只有美国公民或永久居民才有资格。一个为期两年的研究承诺是必需的，和MD学员预计已完成至少三年的博士后培训之前，开始奖学金。为了了解创伤和脓毒症中器官衰竭的细胞和分子机制，受训人员将在科学导师的指导下被安置在实验室，那里有最先进的科学方法，导师致力于培训医生/科学家。来自校园众多部门的教师的加入产生了多样化的计划，被选为潜在导师的个人是国内/国际公认的科学家，他们与外科系的研究人员有着长期的合作历史。在UT西南部研究的多样性检查损伤和炎症反应，使潜在的学员检查创伤，败血症，炎症和重症监护的病理生理机制。创伤和败血症构成了当今社会医疗保健费用的主要部分。最终改善危重患者预后的临床创新的发展有望减少住院时间，并减轻创伤和脓毒症产生的巨大经济负担。因此，本文所述的研究和培训与公共卫生问题和关切特别相关。

DESCRIPTION (provided by applicant): The specific aim of this competitive renewal of our training program in Trauma, Sepsis, Inflammation, and Critical Care is to develop physician/scientists who are well grounded in physiology, molecular biology, and molecular genetics. This program is designed to teach interested individuals to develop hypothesis-based research plans, enabling the trainees to transfer developments and new information from bench to bedside, leading to the development of novel and innovative therapeutic strategies in trauma and critical care. This training program is devoted to two years research training, and candidates for the training program must have an MD or PhD degree from an accredited medical or graduate school; only United States citizens or permanent residents are eligible. A two-year research commitment is required, and MD trainees are expected to have completed at least three years of postdoctoral training prior to beginning the fellowship. To achieve an understanding of the cellular and molecular mechanisms underlying organ failure in trauma and sepsis, trainees are placed in laboratories under the direction of scientific preceptors where state-of-the-art scientific methods are available and preceptors are committed to the training of physician/scientists. The inclusion of faculty from numerous departments across campus has produced a diverse program, and individuals selected as potential preceptors are nationally/internationally recognized scientists who have a long-term history of collaboration with investigators in the Department of Surgery. A diversity of research at UT Southwestern examines injury and inflammatory responses, enabling potential trainees to examine pathophysiologic mechanisms of trauma, sepsis, inflammation, and critical care. Trauma and sepsis constitute a major portion of health care costs in today's society. The development of clinical innovations that ultimately improve outcome of critically ill patients would be expected to reduce hospital stay and reduce the enormous financial burden that trauma and sepsis produce. Thus, the research and training described herein are particularly relevant to public health issues and concerns.