Neuropsychology AIDS Fellowship

描述（由申请人提供）：在过去的15年里，加州大学洛杉矶分校HIV神经心理学培训项目（T32 19535）一直致力于HIV感染神经心理学后遗症研究的博士后培养。受资助的研究领域包括艾滋病毒的神经认知和神经精神影响研究、神经认知障碍的功能影响（如药物依从性、驾驶能力）、艾滋病毒感染的自然史研究（MACS研究）、脑行为异常的相关研究（NNTC）、药物试验、药物滥用、艾滋病毒疾病的功能神经影像学、基因型对神经系统损害、衰老和艾滋病的影响研究。以及hiv - C型肝炎合并感染。汇集了神经心理学、临床心理学、神经学、精神病学、少数民族心理健康和健康差异、传染病、公共卫生、护理学、社会学、流行病学、初级预防、神经影像学、行为遗传学、药物滥用和生物统计学等多学科的专家。研究员在他们感兴趣的项目上与初级和二级导师一起工作。本申请要求资助三名博士后，每人至少两年。研究员将投入至少75%的研究相关责任。他们还将接受广泛的教学，包括每周四花一整天的时间来完成正式课程。他们还将通过对艾滋病毒疾病和其他神经系统疾病患者进行神经心理学评估获得临床经验。助学金方面的培训也受到重视。与公共卫生的相关性：研究艾滋病毒感染的下一代神经心理学家必须接受培训，以应对新出现的挑战，如医疗合并症（例如，丙型肝炎合并感染、药物滥用、精神疾病），以及流行病“老龄化”后与年龄相关的合并症。功能神经影像学的进步需要纳入训练计划，同时也需要增加对遗传多态性贡献的认识，以及探索死后神经病理学发现与其死前神经心理学表现之间关系的相关研究。在药物依从性、驾驶安全、财务资金和职业健康等领域，针对HIV相关神经认知能力下降的功能后果的研究和培训也值得更多关注。这项培训补助金的续期将使我们能够继续开展这项工作，适应随着艾滋病毒流行病性质的变化而出现的新挑战，并继续培训致力于研究和治疗艾滋病毒疾病的下一代神经心理学家。

DESCRIPTION (provided by applicant): For the past 15 years the UCLA Neuropsychology of HIV Training Program (T32 19535) has been dedicated to postdoctoral training in research on the neuropsychological sequelae of HIV infection. Funded research areas open to fellow involvement include study of neurocognitive and neuropsychiatric effects of HIV, the functional effects (e.g. medication adherence, driving ability) of neurocognitive impairment, study of the natural history of HIV infection (MACS study), correlative study of brain-behavior abnormalities (NNTC), medication trials, substance abuse, functional neuroimaging of HIV disease, study of genotypic contributions to neurological compromise, aging and AIDS, and HIV-Hepatitis C co-infection. A multidisciplinary faculty has been assembled with expertise in neuropsychology, clinical psychology, neurology, psychiatry, minority mental health and health disparities, infectious disease, public health, nursing, sociology, epidemiology, primary prevention, neuroimaging, behavioral genetics, substance abuse, and biostatistics. Fellows work with primary as well as secondary mentors on projects of their interest. This application requests funding to support three postdoctoral fellows for a period of at least two years each. Fellows will devote at least 75% to research related responsibilities. They will also receive extensive didactics, including devoting all day every Thursday to formal coursework. They will also gain clinical experience through the provision of neuropsychological evaluation of patients with HIV disease and other neurological disorders. Training in grantsmanship is also emphasized. Relevance to Public Health: The next generation of neuropsychologists studying HIV infection must be trained to deal with emerging challenges such as medical comorbidities (e.g., Hepatitis C co-infection, substance abuse, psychiatric illness), and age-related co-morbidities secondary to the "graying" of the epidemic. Advances in functional neuroimaging need to be incorporated into training programs as does increased recognition of the contribution of genetic polymorphisms and correlative study exploring the relationship between post-mortem neuropathologic findings and their ante-mortem neuropsychological manifestations. Research and training targeting the functional ramifications of HIV associated neurocognitive decline in areas such as medication adherence, driving safety, financial wherewithal, and occupational fitness merit increased attention as well. Renewal of this training grant will allow us to continue this body of work, adapt to new emerging challenges attendant to the changing nature of the HIV pandemic, and continue to train the next generation of neuropsychologists who are committed to research and treatment of HIV disease.