Disinfection by-products formed during drinking water treatment: reducing the unknowns is managing risk

饮用水处理过程中形成的消毒副产物：减少未知数就是管理风险

• 批准号: DP140102672
• 负责人: Prof Matti Lang
• 金额: $ 19.39万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140102672
• 关键词: Disinfection; products; formed; during; drinking

Disinfection of drinking water is a successful measure to reduce water-borne diseases and protect health. However, epidemiological evidence links bladder cancer to disinfection by-products formed during drinking water treatment. Despite decades of research the causative agents remain to be identified. To fill this knowledge gap, this project will quantify the fraction of toxicity that cannot be explained by known chemicals in water samples treated with different disinfectants using a combination of chemical analysis and in-vitro bioassays. Samples with high unexplained effects will then be fractionated to isolate toxicologically relevant disinfection by-products, which will ultimately be identified with non-target chemical analysis.

饮用水消毒是减少水媒疾病和保护健康的成功措施。然而，流行病学证据将膀胱癌与饮用水处理过程中形成的消毒副产品联系起来。尽管经过几十年的研究，病原体仍有待确定。为了填补这一知识空白，该项目将使用化学分析和体外生物测定相结合的方法，量化用不同消毒剂处理的水样中已知化学物质无法解释的毒性部分。然后将具有高度不明原因影响的样本进行分级，以分离毒理学相关的消毒副产物，最终将通过非目标化学分析进行识别。