Modulation of macrophage function as a therapy for chronic obstructive pulmonary disease (COPD)

调节巨噬细胞功能作为慢性阻塞性肺疾病 (COPD) 的治疗方法

• 批准号: nhmrc : 626972
• 负责人: A/Pr Greg Hodge
• 金额: $ 29.05万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulation-macrophage-function-disease-copd/76201
• 关键词: Modulation; macrophage; function; therapy; chronic

We have established that defective clearance of dying cells by phagocytes in the airway can a) perpetuate inflammation in smokers with-without COPD and b) be improved by administration of therapies (Mannose binding lectin and Procysteine) in a mouse model. The current proposal specifically addresses the role of phagocytes in the ongoing airway damage in our COPD patients, and more thoroughly investigates the mechanisms and effects of administration of relevant new therapies (in a mouse model).

我们已经确定气道中吞噬细胞对死亡细胞的清除缺陷可以a)使有-无COPD的吸烟者的炎症持续存在，b)在小鼠模型中通过治疗（甘露糖结合凝集素和半胱氨酸）得到改善。目前的提案专门针对吞噬细胞在COPD患者持续气道损伤中的作用，并更彻底地研究相关新疗法的机制和作用（在小鼠模型中）。