Modulation of macrophage function as a therapy for chronic obstructive pulmonary disease (COPD)

我们已经确定气道中吞噬细胞对死亡细胞的清除缺陷可以a)使有-无COPD的吸烟者的炎症持续存在，b)在小鼠模型中通过治疗（甘露糖结合凝集素和半胱氨酸）得到改善。目前的提案专门针对吞噬细胞在COPD患者持续气道损伤中的作用，并更彻底地研究相关新疗法的机制和作用（在小鼠模型中）。

We have established that defective clearance of dying cells by phagocytes in the airway can a) perpetuate inflammation in smokers with-without COPD and b) be improved by administration of therapies (Mannose binding lectin and Procysteine) in a mouse model. The current proposal specifically addresses the role of phagocytes in the ongoing airway damage in our COPD patients, and more thoroughly investigates the mechanisms and effects of administration of relevant new therapies (in a mouse model).