The Role of Apoptosis and Macrophage Function in Chronic Obstructive Pulmonary Disease

细胞凋亡和巨噬细胞功能在慢性阻塞性肺疾病中的作用

• 批准号: nhmrc : 349337
• 负责人: A/Pr Greg Hodge
• 金额: $ 30.9万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-apoptosis-macrophage-pulmonary-disease/77021
• 关键词: Role; Apoptosis; Macrophage; Function; Chronic

Chronic obstructive pulmonary disease (COPD) is a complex, chronic disease of the lungs principally caused by cigarette smoking. COPD is very common and causes a great deal of debility and mortality in our community. COPD is also linked to an increased risk of lung cancer and carviovascular disease. It is estimated to cost Australians at least $800 million dollars per year in health related costs. Despite its importance, there is a limited understanding of how COPD develops and treatment options are limited. We have identified large numbers of dying cells in the airways of people with COPD and we believe that these play a critical part in the cause and-or progression of the illness. This project will determine whether the increased rates of cell death are the result of the COPD process or part of the actual cause of the disease. This knowledge will enable us to address the urgent need to predict the risk of developing COPD in current and ex- smokers. Cells obtained from the lungs of healthy controls, current- ex smokers without COPD and current- ex smokers with COPD will be studied. The effects of current treatments for COPD on these cells as well as testing novel treatments will also be studied, paying particular attention to the effects on cell death. In this way we hope that new therapies will be identified to improve the health and well-being of those with COPD.

慢性阻塞性肺病（COPD）是一种复杂的慢性肺部疾病，主要由吸烟引起。慢性阻塞性肺病（COPD）非常常见，在我们的社区中造成大量的虚弱和死亡。慢性阻塞性肺病还与肺癌和心血管疾病的风险增加有关。据估计，澳大利亚人每年至少花费 8 亿澳元的健康相关费用。尽管它很重要，但人们对慢性阻塞性肺病如何发展的了解有限，治疗选择也有限。我们在慢性阻塞性肺病患者的气道中发现了大量濒临死亡的细胞，我们相信这些细胞在疾病的病因和/或进展中发挥着关键作用。该项目将确定细胞死亡率的增加是慢性阻塞性肺病过程的结果还是该疾病的实际原因的一部分。这些知识将使我们能够满足预测当前吸烟者和戒烟者患慢性阻塞性肺病的风险的迫切需要。我们将从健康对照者、目前未患慢性阻塞性肺病（COPD）的戒烟者和患有慢性阻塞性肺病（COPD）的戒烟者的肺部获得细胞进行研究。还将研究当前慢性阻塞性肺病治疗对这些细胞的影响以及测试新的治疗方法，特别关注对细胞死亡的影响。通过这种方式，我们希望能够找到新的疗法来改善慢性阻塞性肺病患者的健康和福祉。