Patient Reported Outcomes of Cervical Screening in HIV+ Women in Zambia
Patient Reported Outcomes of Cervical Screening in HIV+ Women in Zambia
批准号:
7674542
负责人:
Eric Chamot
金额:
$14.18万
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-08-14 至 2012-07-31
关键词:
AIDS/HIV problemAcetic AcidsAddressAdherenceAdvocateAfricaAfricanAgeAmbulatory Care FacilitiesAnti-Retroviral AgentsAnxietyBackBehaviorBehavioral ResearchCancer BurdenCancer ControlCaringCervicalCervical Cancer ScreeningCervical Intraepithelial NeoplasiaCervical dysplasiaCervix UteriChildClinicCold TherapyCounselingCountryDNADataDecision MakingDeveloped CountriesDeveloping CountriesDevelopmentDiagnosisDimensionsDiseaseDistressEconomic ModelsEconomicsEligibility DeterminationEnsureEquipment and supply inventoriesEthicsExerciseFemale AdolescentsFoundationsFutureGeneric DrugsGoalsGrantGuidelinesHIVHealthHealth ServicesHealth StatusHealth SurveysHealthcareHuman PapillomavirusImageImmunosuppressionInfectious Diseases ResearchInternationalInterventionIntervention TrialInterviewInvestigationLanguageLearningLesionLifeLoop electrosurgical excision procedureMalignant neoplasm of cervix uteriMarketingMeasuresMental HealthMethodologyMethodsMinorMonitorNursesOutcomeOutcomes ResearchParticipantPatient Outcomes AssessmentsPatientsPatternPerformancePhasePoliciesPremalignantPreventionProceduresProcessProtocols documentationPublishingQuality-Adjusted Life YearsQuality-of-Life AssessmentQuestionnairesRandomized Controlled Clinical TrialsRecommendationReportingResearchResearch Project GrantsResourcesSF-36SamplingScheduleScreening ResultScreening procedureSexualitySolidSpecific qualifier valueSpecificitySpeculumsStagingSystemTanzaniaTarget PopulationsTeaching HospitalsTechnologyTestingTimeTranslatingTreatment EfficacyTuberculosisUniversitiesUpdateUrineVaginaVisitVisualVulvaWeightWomanWomen&aposs GroupWomen&aposs HealthWritingZambiabasecare seekingcervical cancer preventioncostcost effectivenessdesigndigitaldigital imagingefficacy testingexperiencefollow-uphealth related quality of lifehigh riskinstrumentnew technologypatient orientedphysical conditioningpreferenceprogramspsychologicpsychological distresspsychosocialreproductiveresearch studyresponsesuccesstheoriestraituptakewillingness to pay
中文摘要
2004年,全世界每5名死于宫颈癌的妇女中就有1名死于浸润性宫颈癌
英文摘要
In 2004, 1 woman died from invasive cervical cancer (ICC) worldwide for every 5 women who died from
HIV/AIDS and 1 woman died from ICC in Africa for 5 women who died from tuberculosis. In Zambia, the
second country with the highest ICC burden in the world after Tanzania, adherence to follow-up
recommendation is currently low among women screened for cervical precursor lesion, and there is anecdotal
evidence that participants experience substantial anxiety and screening-related distress. In this R21
exploratory/developmental proposal written in response to PA-06-351 for Behavioral Research in Cancer
Control, we intend to carry out formative and patient-centered research (1) to assess the short-term effects of
screening by Visual Inspection of the cervix after application of Acetic Acid (VIA) on the health-related quality
of life (HRQoL) of HIV+ and HIV- women in Lusaka, Zambia; (2) to compare the acceptability of existing
screening protocols and screening options in development but not yet available. The proposed study will
serve as an empirical foundation for the design and conduct of an intervention trial aiming at minimizing
psychosocial harms and increasing acceptability of cervical screening. The R21 study will be conducted in the
following four phases:
We will culturally adapt and rigorously translate the SF-36v2 Health Survey, the Cervical Dysplasia Distress
Questionnaire, and state scale of the Spielberger's State-Trait Anxiety Inventory (6-item version) in two
languages widely spoken in the Southern African region. We will also test the feasibility of using Discrete
Choice Experiments to uncover women's preferences for VIA screening and alternative screening options
currently in early testing phase. Then, we will interview 360 women offered VIA screening at CIDRZ
clinics in Lusaka at baseline, before screening. Women who accept to undergo testing will be
interviewed two more times, immediately after cervical screening and at 1-month post-screening. Data
generated will be used to validate the instruments and methods adapted in the Development Phase, and test
research hypotheses about adverse outcomes and acceptability of low-technology cervical screening in
Zambia. Estimates of quality weights for screening-related health states will also be generated as a study
byproduct. With one woman dying from cervical cancer worldwide for every five women who die from HIV/AIDS, low-
technology cervical screening programs are increasingly proposed as imperfect but potentially cost-effective
approaches to reduce cervical cancer burden in the developing world. This exploratory research project
aims to identify ways to maximize the acceptability of same-day cervical cancer screening and
treatment, minimize the adverse psychosocial consequences of screening, and ensure adherence to
post-screening recommendations among both HIV-infected and HIV-uninfected women attending
outpatient clinics in Lusaka, Zambia.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
DOI:
10.3109/0167482x.2012.656161
发表时间:
2012-06
期刊:
Journal of psychosomatic obstetrics and gynaecology
影响因子:
--
作者:
[White HL, Mulambia C, Sinkala M, Mwanahamuntu MH, Parham GP, Kapambwe S, Moneyham L, Kempf MC, Chamot E]
通讯作者:
Chamot E
Patient Reported Outcomes of Cervical Screening in HIV+ Women in Zambia
-
批准号:7418899
-
项目类别:
-
资助金额:$17.01万
-
财政年份:2008
-
负责人:Eric Chamot
-
依托单位:
UAB International Clinical Research/Management Training
-
批准号:7071691
-
项目类别:
-
资助金额:$100.0万
-
财政年份:2003
-
负责人:Eric Chamot
-
依托单位:
UAB International Clinical Research/Management Training
-
批准号:6757998
-
项目类别:
-
资助金额:$100.0万
-
财政年份:2003
-
负责人:Eric Chamot
-
依托单位:
UAB International Clinical Research and Management Training Program
-
批准号:7232294
-
项目类别:
-
资助金额:$100.0万
-
财政年份:2003
-
负责人:Eric Chamot
-
依托单位:
UAB International Clinical Research/Management Training
-
批准号:6613522
-
项目类别:
-
资助金额:$100.0万
-
财政年份:2003
-
负责人:Eric Chamot
-
依托单位:
UAB International Clinical Research/Management Training
-
批准号:6898840
-
项目类别:
-
资助金额:$100.0万
-
财政年份:2003
-
负责人:Eric Chamot
-
依托单位:
海外基金