Neurovascular Control in Postural Tachycardia Syndrome (POTS)

姿势性心动过速综合征 (POTS) 的神经血管控制

• 批准号: 7640798
• 负责人: MICHAEL J JOYNER
• 金额: $ 24.86万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7640798
• 关键词: Address; Adrenergic Agents; Autonomic nervous system disorders; Baroreflex; Blood Pressure; Blood flow; Cardiac Output; Cardiovascular system; Equilibrium; Exercise; Fc Receptor; Goals; Heart Rate; Human; Impairment; Limb structure; Mediating; Muscle; Patients; Peripheral; Reflex action; Rest; Stress; Syndrome; Tachycardia; Testing; Vasoconstrictor Agents; Vasodilation; adrenergic; falls; pressure; response; restraint; vasoconstriction

The overall goal of project 3 is to explore cardiovascular control mechanisms in human autonomic disorders. Our focus during this cycle will be to determine if the Postural Orthostatic Tachycardia Syndrome (POTS) is associated with fundamental alterations in vasoconstrictor function at rest and during exercise. Our major hypotheses are that a) adrenergic vasoconstriction is blunted in POTS, b) cardiac output, but not blood pressure, will rise normally during exercise in patients with POTS, and c) sympathetic restraint of blood flow to active muscles will be absent in POTS. Together these impairments will evoke excessive reflex increases in heart rate during orthostatic stress or dynamic exercise in patients with POTS.

项目3的总体目标是探索人类自主神经疾病的心血管控制机制。