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Neurovascular Control in Postural Tachycardia Syndrome (POTS)

Neurovascular Control in Postural Tachycardia Syndrome (POTS)
姿势性心动过速综合征 (POTS) 的神经血管控制
批准号:
7640798
负责人:
MICHAEL J JOYNER
金额:
$24.86万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-08-01 至 2010-07-31

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中文摘要
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英文摘要
The overall goal of project 3 is to explore cardiovascular control mechanisms in human autonomic disorders. Our focus during this cycle will be to determine if the Postural Orthostatic Tachycardia Syndrome (POTS) is associated with fundamental alterations in vasoconstrictor function at rest and during exercise. Our major hypotheses are that a) adrenergic vasoconstriction is blunted in POTS, b) cardiac output, but not blood pressure, will rise normally during exercise in patients with POTS, and c) sympathetic restraint of blood flow to active muscles will be absent in POTS. Together these impairments will evoke excessive reflex increases in heart rate during orthostatic stress or dynamic exercise in patients with POTS.
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Variant Hemoglobin and Cardiorespiratory Regulation in Humans
  • 批准号:
    10320441
  • 项目类别:
  • 资助金额:
    $80.62万
  • 财政年份:
    2018
  • 负责人:
    MICHAEL J JOYNER
  • 依托单位:
Variant Hemoglobin and Cardiorespiratory Regulation in Humans
  • 批准号:
    10532798
  • 项目类别:
  • 资助金额:
    $80.62万
  • 财政年份:
    2018
  • 负责人:
    MICHAEL J JOYNER
  • 依托单位:
Variant Hemoglobin and Cardiorespiratory Regulation in Humans
  • 批准号:
    10065009
  • 项目类别:
  • 资助金额:
    $80.62万
  • 财政年份:
    2018
  • 负责人:
    MICHAEL J JOYNER
  • 依托单位:
Perfusion of Active Muscles: Metabolites and Nerves
  • 批准号:
    7822178
  • 项目类别:
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  • 财政年份:
    2009
  • 负责人:
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  • 依托单位:
海外基金