Development of hybrid neural prosthetic devices

混合神经假体装置的开发

基本信息

  • 批准号:
    7492817
  • 负责人:
  • 金额:
    $ 19.73万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-09-01 至 2009-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The convergence of nanotechnology and neuroscience holds promise for the successful development of external electronic devices capable of interfacing with the central nervous system (CNS). In recent years, considerable progress has been made in the fabrication of electronic devices at the micro- and nano-scales. However, it remains to be discovered how biological components can be successfully integrated with these devices. The long-term goal of our research project is to develop a series of hybrid neural prosthetic devices, consisting of biological components with digital integration that will allow the simultaneous measurement, and stimulation, of neural events in the CNS. The central hypothesis of this application is that the integration of biological components with neural prosthetic devices, will promote their successful integration with the mammalian CNS, to enhance long-term device performance. We will use research strategies from a variety of disciplines, including neuroscience, nanotechnology, computer sciences and engineering to accomplish our goals. The specific aims of this project are to: (i) develop methodologies for the design and construction of hybrid neural prosthetic devices; and, (ii) assess the functionality of hybrid devices in both in vitro and in vivo settings. The rationale for these studies is that, once we can reliably integrate biological components with neural prosthetic devices, that these basic design features will permit the construction of devices with additional biological units each of which possesses greater complexity. The research design is to use primary cultures of hippocampal pyramidal neurons as the biological components. Neurons will be incorporated with prosthetic devices, using a novel bio-mimetic polymer. The integration of hybrid devices into the CNS will be described using electrophysiological, pharmacological, and morphological methods. We envisage that end stage prosthetic devices will contain both organic and electrical components for providing inputs, controlling network function, and recording outputs. Presently 5.3 million Americans - approximately 2% of the U.S. population - live with disabilities resulting from a traumatic brain injury. The development of hybrid neural prosthetic devices will have the potential to restore function to people who suffer from a diverse range of neurological disabilities.
描述(由申请人提供):纳米技术和神经科学的融合为成功开发能够与中枢神经系统(CNS)连接的外部电子设备带来了希望。近年来,微纳米级电子器件的制造取得了长足的进步。然而,如何将生物成分成功地与这些设备集成还有待发现。我们研究项目的长期目标是开发一系列混合神经假体装置,由数字集成的生物组件组成,可以同时测量和刺激中枢神经系统中的神经事件。该应用的中心假设是,生物组件与神经假体装置的整合,将促进它们与哺乳动物中枢神经系统的成功整合,以提高设备的长期性能。我们将使用各种学科的研究策略,包括神经科学,纳米技术,计算机科学和工程来实现我们的目标。该项目的具体目标是:(i)开发设计和构建混合神经假体装置的方法;并且(ii)评估混合装置在体外和体内的功能。这些研究的基本原理是,一旦我们能够可靠地将生物组件与神经假体设备集成在一起,这些基本设计特征将允许构建具有附加生物单元的设备,每个生物单元都具有更大的复杂性。本研究设计以海马锥体神经元原代培养物为生物成分。神经元将与假体装置结合,使用一种新型仿生聚合物。将混合装置集成到中枢神经系统将使用电生理、药理学和形态学方法进行描述。我们设想,最终阶段的假肢设备将包含有机和电子元件,用于提供输入、控制网络功能和记录输出。目前,530万美国人(约占美国人口的2%)患有创伤性脑损伤导致的残疾。混合神经修复装置的发展将有可能恢复患有各种神经残疾的人的功能。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Biomedical Technologies for in vitro Screening and Controlled Delivery of Neuroactive Compounds.
神经活性化合物的体外筛选和控制递送的生物医学技术。
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Matthew Robert Hynd其他文献

Matthew Robert Hynd的其他文献

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{{ truncateString('Matthew Robert Hynd', 18)}}的其他基金

Development of hybrid neural prosthetic devices
混合神经假体装置的开发
  • 批准号:
    7294685
  • 财政年份:
    2007
  • 资助金额:
    $ 19.73万
  • 项目类别:

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