Continuation of Follow-up of DES-exposed Cohorts

继续对 DES 暴露组进行随访

• 批准号: 7584792
• 金额: $ 18.81万
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7584792
• 关键词: Continuation; Follow; up; DES; exposed

1. Maintain contact with the DES-exposed individuals and unexposed controls already being followed in our follow-up program. This will be accomplished through two questionnaires sent to the participants during the period of the contract. 2. Continue to identify new third generation female offspring whose mothers were exposed in utero to DES and to examine these young women in a manner similar to the examination performed on their mothers in enrollment in the DESAD project. 3. Continue to evaluate the incidence of genital tract neoplasia in the exposed and unexposed cohorts as well as the mothers who took DES during their pregnancies. 4. Continue to estimate the incidence of intra epithelial neoplasia of the cervix and vagina. 5. Continue to evaluate the incidence of other benign and malignant neoplasms found in the DES-exposed cohorts. 6. Continue to assess the immunologic status of the subjects by determining the life-time occurrence of autoimmune diseases of exposed individuals as compared to the unexposed. 7. Continue to monitor the occurrence of medical disease in the exposed and unexposed cohorts and to make comparisons among them with published disease rates. 8. Obtain and confirm information of the diagnosis of all reported neoplasms in the DES and control cohorts.

1.与暴露于DES的个体和未暴露的对照保持联系，这些对照已经在我们的后续计划中得到遵循。这将通过在合同期间向参与者发送两份调查问卷来完成。 2.继续查明其母亲在子宫内接触DES的新的第三代女性后代，并以类似于参加DESAD项目时对其母亲进行的检查的方式对这些年轻妇女进行检查。 3.继续评估暴露者和非暴露者以及孕期服用药物的母亲的生殖道肿瘤发病率。 4.继续估计宫颈和阴道上皮内瘤变的发生率。 5.继续评估在接触DES的队列中发现的其他良性肿瘤和恶性肿瘤的发病率。 6.继续评估受试者的免疫状况，方法是确定与未接触者相比，暴露者自身免疫性疾病的终生发生率。 7.继续监测暴露人群和未暴露人群中的医疗疾病发生情况，并将其与公布的发病率进行比较。 8.获取并确认DES和对照队列中所有已报告肿瘤的诊断信息。