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The University of Michigan George M O'Brien Renal Core Center

密歇根大学乔治·M·奥布莱恩肾脏核心中心

基本信息

批准号：
7679129
负责人：
ROGER Charles WIGGINS
金额：
$ 75.16万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7679129
关键词：
Affect African American Animal Model Applied Genetics Automobile Driving Back Basic Science Biological Models Childhood Clinic Clinical Clinical Trials Collaborations Communities Cost Sharing Databases Decision Analysis Descriptor Development Disease Elements Faculty Genetic Predisposition to Disease Genome Genotype Goals Grant Hispanics Histology Human Individual Institution Intervention Investigation Kidney Kidney Diseases Knowledge Lighting Maintenance Maps Medical Students Medicine Michigan Microscopy Minority Molecular Online Systems Outcome Pathologic Pathway interactions Phenotype Population Postdoctoral Fellow Prevention Prevention approach Private Sector Process Recruitment Activity Renal glomerular disease Research Research Infrastructure Research Personnel Resources Sampling Signal Pathway Signal Transduction Staging Structure System Systems Biology Talents Technology Therapeutic Transgenic Organisms Translating Translational Research Translations Universities Viral Vector Work age group base biobank clinical application clinical phenotype high risk human disease molecular marker molecular pathology new technology programs response sample collection tool transcriptomics user-friendly

项目摘要

DESCRIPTION, OVERALL (provided by applicant): The focus for the George M. O'Brien Kidney Centers has been basic science investigation that has very successfully defined kidney structure, function and disease mechanisms. New technologies now provide opportunities to translate these remarkable basic science advances to the clinic in ways not previously imaginable. Advances in identification of genetic susceptibilities as well as the advent of the genome project and systems biology technologies set the stage for development of molecular maps that can be superimposed on traditional pathologic and functional descriptors so as to define diseases in a new way. These developments have important implications for definition of molecular markers that will allow accurate individualized prediction of outcome and response to therapy, and the identification of key pathways for therapeutic attack. The University of Michigan has developed and recruited expertise to help exploit these opportunities for people with kidney diseases. The realization of these opportunities requires collaborations between investigators world-wide for the collection of samples from well characterized individuals and populations, the application of technologies that facilitate information availability and exchange, the development and maintenance of databanks, and the integration of these technologies between human diseases, animals models, cellular systems and molecular signaling so as to define key pathways driving renal disease processes. Towards these goals the O'Brien Kidney Research Core Center at the University of Michigan will support four Cores: A. An Applied Systems Biology Core that has developed the platforms and infrastructure necessary to serve the integrative functions outlined above; B. A Clinical Phenotyping and Biobank Core that will collect the biosamples from affected characterized individuals; C. An Applied Genetics Core that will perform mutational analysis for genotype/phenotype matching; and D. A Basic Research Enhancement Core that will facilitate basic science development, integration and translation. These cores together with the Pilot and Feasibility Projects and Educational Enhancement Program in the Administrative Core will coordinate the grant, utilize the Cores and attract and support new talent into kidney research. The University of Michigan will provide $1,000,000 in supplemental support for the Center. The aim is to develop a structure which will serve local and national kidney investigators and the kidney community at large. Using web based tools, we will provide the basis for new understanding of disease-specific molecular pathology that can be used by every kidney investigator in the public and private sector world-wide.

总体描述（由申请人提供）：