Clinical Centers for the Osteoarthritis Initiative

膝关节骨关节炎（OA）是成人残疾的最常见原因。“骨关节炎倡议（OAI）：膝关节健康研究”是一项全国性的研究，将帮助研究人员收集更多关于关节炎症状发作前或OA恶化前发生的身体变化的信息。本研究的目的是检查患有膝关节OA或膝关节OA高风险的人;信息将用于更好地了解如何预防和治疗膝关节OA膝关节OA会导致更多的健康问题和医疗费用，任何其他形式的关节炎。OA的症状可以从僵硬和轻度疼痛到严重的关节疼痛甚至残疾。先前的研究表明，某些因素，如膝关节疼痛，先前的膝关节损伤或膝关节手术，手OA或肥胖，可能导致膝关节OA。OAI是一项膝关节OA的多中心观察性研究，将收集OA的潜在生物标志物以及OA发作和进展趋势的信息。OAI将在四个临床中心之一招募并随访患有膝关节OA或膝关节OA高风险的参与者至少四年。将在每年4次随访访视时完成血液和尿液采集、磁共振成像（MRI）和X线检查。筛选时的问卷调查和体格检查将评估膝关节OA发生和进展的风险因素。将在研究开始时和每次随访访视时通过问卷和检查评估膝关节疼痛和身体残疾的水平。

Knee osteoarthritis (OA) is the most common cause of disability in adults. The "Osteoarthritis Initiative (OAI): A Knee Health Study" is a nationwide research study that will help researchers gather more information about the physical changes that occur prior to the onset of arthritis symptoms or before OA gets worse. The purpose of this study is to examine people who have knee OA or are at high risk for knee OA; information will be used to better understand how to prevent and treat knee OA Knee OA causes more health problems and medical expenses that any other form of arthritis. Symptoms of OA can range from stiffness and mild pain to severe joint pain and even disability. Previous research has shown that certain factors, such as knee pain, prior knee injury or knee surgery, OA of the hand, or obesity, may lead to knee OA. The OAI is a multicenter, observational study of knee OA that will collect information on potential biomarkers for OA and trends in OA onset and progression. The OAI will recruit and follow participants who have knee OA or are at high risk for developing knee OA for at least a four-year period at one of four clinical centers. Blood and urine collection, magnetic resonance imaging (MRI), and X-rays will be completed at each of four annual follow-up visits. A questionnaire and physical examination at screening will assess for risk factors for the development and progression of knee OA. Levels of knee pain and physical disability will be assessed at study start and at each of the follow-up visits by questionnaire and examination.