CORE--VECTOR PRODUCTION

核心——矢量制作

• 批准号: 7922018
• 负责人: PETER KIEM HANS
• 金额: $ 22.72万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7922018
• 关键词: Adenovirus Vector; Adenoviruses; Affect; Alkaline Phosphatase; Alleles; Animal Experiments; Animal Model; Animals; Aspirate substance; Biological Assay; Blood Cells; CD34 gene; Canis familiaris; Cell Count; Cell Differentiation process; Cell Line; Cell Nucleus; Cell Separation; Cell division; Cell surface; Cells; Chemotherapy-Oncologic Procedure; Chromosomes; Clinic; Clinical; Clinical Research; Clone Cells; Cloning; Cloning Vectors; Code; Complementary DNA; Complex; Computer software; Consultations; Cytomegalovirus; Cytoplasm; DNA; DNA Sequence Rearrangement; Data; Detection; Development; Diploid Cells; Disease; Dose; Double-Stranded RNA; Early Promoters; Elements; Engineering; Engraftment; Enhancers; Ensure; Event; Family; Fibronectins; Flow Cytometry; Frequencies; Friends; Future; Gene Delivery; Gene Expression; Gene Transfer; Gene-Modified; Generations; Genes; Genetic; Genetic Recombination; Genetic Transcription; Genome; Gibbon Ape Leukemia Virus vector; Globin; Glycoproteins; Green Fluorescent Proteins; HIV; HIV-1; Helper Viruses; Hematology; Hematopoietic; Hematopoietic stem cells; Hereditary Disease; Homing; Hour; Human; Hybrids; Immune; Immunologic Deficiency Syndromes; In Vitro; Incubated; Incubators; Individual; Infection; Introns; Laboratories; Lead; Left; Lentivirus Vector; Link; Locus Control Region; Lymphoid Tissue; Malignant Neoplasms; Measures; Mediating; Memory; Messenger RNA; Methods; Mitosis; Modeling; Modification; Molecular; Monitor; Monkeys; Monoclonal Antibodies; Mus; Mutagens; Mutation; NGFR Protein; NOD/SCID mouse; Nature; Nerve Growth Factor Receptors; Oncogene Activation; Outcome; Papio; Paris, France; Patients; Pattern; Pharmaceutical Preparations; Phenotype; Phleomycins; Plasmids; Polyadenylation; Population; Pre-Clinical Model; Precipitation; Preparation; Primates; Probability; Production; Property; Protamine Sulfate; Proto-Oncogenes; Protocols documentation; Proviruses; RNA Interference; Regulator Genes; Regulatory Element; Reporter; Reporter Genes; Reporting; Research; Research Personnel; Resistance; Rest; Retroviral Vector; Retroviridae; Reverse Transcription; Risk; Safety; Screening procedure; Sequence Deletion; Series; Serotyping; Services; Sickle Cell Anemia; Site; Sorting - Cell Movement; Stem cells; Subfamily lentivirinae; System; T memory cell; T-Cell Leukemia; T-Lymphocyte; Technology; Testing; Therapeutic; Time; Training; Transcription Initiation Site; Transfection; Transgenes; Transplantation; Variant; Vertebral column; Vesicular stomatitis Indiana virus; Viral; Viral Vector; Virion; Virus; Virus Receptors; Woodchuck Hepatitis B Virus; adeno-associated viral vector; adenosine deaminase deficiency; animal data; base; calcium phosphate; cell type; cellular transduction; clinical application; cytokine; density; design; env Genes; experience; expression cloning; feeding; gastrointestinal; gene correction; gene function; gene therapy; gene transfer vector; genetically modified cells; graft versus host disease induction; graft vs host disease; hematopoietic repopulating cell; improved; in vivo; interest; killings; large scale production; lentiviral-mediated; leukemia; leukemogenesis; mouse model; nonhuman primate; novel; overexpression; pre-clinical; preference; premature; promoter; receptor; receptor expression; research study; safety testing; self-renewal; therapeutic transgene; tool; transduction efficiency; transmission process; tumor; vector; vif Genes; viral RNA; virus envelope

ABSTRACT NOT PROVIDED

未提供摘要